Universität zu Köln

Charisse, Daniel, Erus, Guray ORCID: 0000-0001-6633-4861, Pomponio, Raymond, Gorges, Martin, Schmidt, Nele, Schneider, Christine, Liepelt-Scarfone, Inga, Riedel, Oliver, Reetz, Kathrin, Schulz, Joerg B., Berg, Daniela, Storch, Alexander, Witt, Karsten, Dodel, Richard, Kalbe, Elke, Kassubek, Jan ORCID: 0000-0002-7106-9270, Hilker-Roggendorf, Rudiger and Baudrexel, Simon (2022). Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease. Neurobiol. Aging, 109. S. 31 - 43. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

Full text not available from this repository.

Abstract

Recently, it was shown that patients with Parkinson's disease (PD) who exhibit an Alzheimer's disease (AD)-like pattern of brain atrophy are at greater risk for future cognitive decline. This study aimed to investigate whether this association is domain-specific and whether atrophy associated with brain aging also relates to cognitive impairment in PD. SPARE-AD, an MRI index capturing AD-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort. All patients underwent an extensive neuropsychological test battery. Patients diagnosed with mild cognitive impairment or dementia were found to have higher SPARE-AD scores as compared to patients with normal cognition and healthy controls. All patient groups showed increased brain age. SPARE-AD predicted impairment in memory, language and executive functions, whereas advanced brain age was associated with deficits in attention and working memory. Data suggest that SPARE-AD and brain age are differentially related to domain-specific cognitive decline in PD. The underlying pathomechanisms remain to be determined. (c) 2021 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Charisse, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Erus, Guray UNSPECIFIED orcid.org/0000-0001-6633-4861 UNSPECIFIED Pomponio, Raymond UNSPECIFIED UNSPECIFIED UNSPECIFIED Gorges, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nele UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Joerg B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Hilker-Roggendorf, Rudiger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baudrexel, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-605136
DOI:	10.1016/j.neurobiolaging.2021.08.020
Journal or Publication Title:	Neurobiol. Aging
Volume:	109
Page Range:	S. 31 - 43
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WHITE-MATTER HYPERINTENSITIES; DOPAMINERGIC DEFICITS; DIAGNOSTIC-CRITERIA; EXECUTIVE FUNCTION; CSF BIOMARKERS; TASK-FORCE; DEMENTIA; MILD; DECLINE; MRI Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/60513