Malapelle, Umberto ORCID: 0000-0003-3211-9957, Pisapia, Pasquale ORCID: 0000-0002-6429-0620, Iaccarino, Antonino, Barberis, Massimo ORCID: 0000-0002-0943-4804, Bellevicine, Claudio, Brunnstrom, Hans ORCID: 0000-0001-7402-138X, de Biase, Dario ORCID: 0000-0002-0609-8817, De Maglio, Giovanna, Lindquist, Kajsa Ericson, Fassan, Matteo ORCID: 0000-0001-6515-5482, Fontanini, Gabriella, Gruppioni, Elisa ORCID: 0000-0002-4334-6170, Hofman, Paul, Merkelbach-Bruse, Sabine, Vila, Miguel A. Molina, Pujals, Anais, Rapa, Ida, Righi, Luisella, Rosell, Rafael, Schildgen, Oliver ORCID: 0000-0003-4297-9627, Schildgen, Verena, Schmitt, Fernando C., Tallini, Giovanni ORCID: 0000-0003-0113-6682, Vander Borght, Sara, Vigliar, Elena, Volante, Marco, Wagener-Ryczek, Svenja, Weynand, Birgit and Troncone, Giancarlo (2021). Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe. J. Clin. Pathol., 74 (6). S. 391 - 396. LONDON: BMJ PUBLISHING GROUP. ISSN 1472-4146

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Abstract

Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Malapelle, UmbertoUNSPECIFIEDorcid.org/0000-0003-3211-9957UNSPECIFIED
Pisapia, PasqualeUNSPECIFIEDorcid.org/0000-0002-6429-0620UNSPECIFIED
Iaccarino, AntoninoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barberis, MassimoUNSPECIFIEDorcid.org/0000-0002-0943-4804UNSPECIFIED
Bellevicine, ClaudioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunnstrom, HansUNSPECIFIEDorcid.org/0000-0001-7402-138XUNSPECIFIED
de Biase, DarioUNSPECIFIEDorcid.org/0000-0002-0609-8817UNSPECIFIED
De Maglio, GiovannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindquist, Kajsa EricsonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fassan, MatteoUNSPECIFIEDorcid.org/0000-0001-6515-5482UNSPECIFIED
Fontanini, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruppioni, ElisaUNSPECIFIEDorcid.org/0000-0002-4334-6170UNSPECIFIED
Hofman, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merkelbach-Bruse, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vila, Miguel A. MolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujals, AnaisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rapa, IdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Righi, LuisellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosell, RafaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schildgen, OliverUNSPECIFIEDorcid.org/0000-0003-4297-9627UNSPECIFIED
Schildgen, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, Fernando C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tallini, GiovanniUNSPECIFIEDorcid.org/0000-0003-0113-6682UNSPECIFIED
Vander Borght, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vigliar, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volante, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagener-Ryczek, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weynand, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Troncone, GiancarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605303
DOI: 10.1136/jclinpath-2020-206957
Journal or Publication Title: J. Clin. Pathol.
Volume: 74
Number: 6
Page Range: S. 391 - 396
Date: 2021
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1472-4146
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PathologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60530

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