Berzow, Dirk, Descamps, Diane, Obermeier, Martin, Charpentier, Charlotte, Kaiser, Rolf, Guertler, Lutz, Eberle, Josef, Wensing, Annemarie, Sierra, Saleta, Ruelle, Jean, Gomes, Perpetua ORCID: 0000-0003-3271-8255, Mansinho, Kamal, Taylor, Ninon, Jensen, Bjorn, Doring, Matthias, Sturmer, Martin ORCID: 0000-0003-4300-9315, Rockstroh, Jurgen and Camacho, Ricardo (2021). Human Immunodeficiency Virus-2 (HIV-2): A Summary of the Present Standard of Care and Treatment Options for Individuals Living with HIV-2 in Western Europe. Clin. Infect. Dis., 72 (3). S. 503 - 510. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Human immunodeficiency virus-2 (HIV-2) is endemic in some countries in West Africa. Due to the lower prevalence in industrialized countries, there is limited experience and knowledge on the management of individuals living with HIV-2 in Europe. Compared to HIV-1, there are differential characteristics of HIV-2 regarding diagnostic procedures, the clinical course, and, most importantly, antiretroviral therapy. We integrated the published literature on HIV-2 (studies and reports on epidemiology, diagnostics, the clinical course, and treatment), as well as expert experience in diagnosing and clinical care, to provide recommendations for a present standard of medical care of those living with HIV-2 in Western European countries, including an overview of strategies for diagnosis, monitoring, and treatment, with suggestions for effective drug combinations for first- and second-line treatments, post-exposure prophylaxis, and the prevention of mother-to-child transmission, as well as listings of mutations related to HIV-2 drug resistance and C-C motif chemokine receptor type 5 and C-X-C motif chemokine receptor type 4 coreceptor tropism.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Berzow, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Descamps, DianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermeier, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Charpentier, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guertler, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberle, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wensing, AnnemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sierra, SaletaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruelle, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomes, PerpetuaUNSPECIFIEDorcid.org/0000-0003-3271-8255UNSPECIFIED
Mansinho, KamalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, NinonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jensen, BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doring, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sturmer, MartinUNSPECIFIEDorcid.org/0000-0003-4300-9315UNSPECIFIED
Rockstroh, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Camacho, RicardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605525
DOI: 10.1093/cid/ciaa275
Journal or Publication Title: Clin. Infect. Dis.
Volume: 72
Number: 3
Page Range: S. 503 - 510
Date: 2021
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DRUG-RESISTANCE; HIV-2-INFECTED PATIENTS; CELL COUNT; PCR ASSAY; INFECTION; DOLUTEGRAVIR; ASSOCIATION; INHIBITORS; SURVIVAL; COHORTMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60552

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