Hauke, Daniel J., Schmidt, Andre, Studerus, Erich, Andreou, Christina, Riecher-Roessler, Anita, Radua, Joaquim ORCID: 0000-0003-1240-5438, Kambeitz, Joseph ORCID: 0000-0002-8988-3959, Ruef, Anne, Dwyer, Dominic B., Kambeitz-Ilankovic, Lana, Lichtenstein, Theresa, Sanfelici, Rachele, Penzel, Nora, Haas, Shalaila S., Antonucci, Linda A., Lalousis, Paris Alexandros ORCID: 0000-0001-9642-3080, Chisholm, Katharine, Schultze-Lutter, Frauke, Ruhrmann, Stephan, Hietala, Jarmo ORCID: 0000-0002-3179-6780, Brambilla, Paolo, Koutsouleris, Nikolaos, Meisenzahl, Eva, Pantelis, Christos ORCID: 0000-0002-9565-0238, Rosen, Marlene, Salokangas, Raimo K. R., Upthegrove, Rachel ORCID: 0000-0001-8204-5103, Wood, Stephen J. and Borgwardt, Stefan (2021). Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis. Transl. Psychiatr., 11 (1). LONDON: SPRINGERNATURE. ISSN 2158-3188

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Abstract

Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models' ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40-64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hauke, Daniel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Studerus, ErichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreou, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riecher-Roessler, AnitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radua, JoaquimUNSPECIFIEDorcid.org/0000-0003-1240-5438UNSPECIFIED
Kambeitz, JosephUNSPECIFIEDorcid.org/0000-0002-8988-3959UNSPECIFIED
Ruef, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, Dominic B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz-Ilankovic, LanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lichtenstein, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanfelici, RacheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Penzel, NoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haas, Shalaila S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antonucci, Linda A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lalousis, Paris AlexandrosUNSPECIFIEDorcid.org/0000-0001-9642-3080UNSPECIFIED
Chisholm, KatharineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultze-Lutter, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruhrmann, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hietala, JarmoUNSPECIFIEDorcid.org/0000-0002-3179-6780UNSPECIFIED
Brambilla, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koutsouleris, NikolaosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meisenzahl, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantelis, ChristosUNSPECIFIEDorcid.org/0000-0002-9565-0238UNSPECIFIED
Rosen, MarleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salokangas, Raimo K. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Upthegrove, RachelUNSPECIFIEDorcid.org/0000-0001-8204-5103UNSPECIFIED
Wood, Stephen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605717
DOI: 10.1038/s41398-021-01409-4
Journal or Publication Title: Transl. Psychiatr.
Volume: 11
Number: 1
Date: 2021
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 2158-3188
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL HIGH-RISK; ULTRA-HIGH RISK; STRUCTURED INTERVIEW; MENTAL STATE; SCHIZOPHRENIA; PREDICTION; SYSTEM; PSYCHOPATHOLOGY; PSYCHIATRY; TRANSITIONMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60571

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