Schmutzler, Rita K., Schmitz-Luhn, Bjoern, Borisch, Bettina, Devilee, Peter, Eccles, Diana, Hall, Per, Balmana, Judith, Boccia, Stefania, Dabrock, Peter, Emons, Guenter, Gaissmaier, Wolfgang, Gronwald, Jacek, Houwaart, Stefanie, Huster, Stefan, Kast, Karin, Katalinic, Alexander, Linn, Sabine C., Moorthie, Sowmiya, Pharoah, Paul, Rhiem, Kerstin, Spranger, Tade, Stoppa-Lyonnet, Dominique, van Delden, Johannes Jozef Marten, van den Bulcke, Marc and Woopen, Christiane (2022). Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors. Breast Care. BASEL: KARGER. ISSN 1661-3805

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Abstract

Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitz-Luhn, BjoernUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borisch, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devilee, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eccles, DianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balmana, JudithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boccia, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dabrock, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emons, GuenterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaissmaier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gronwald, JacekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houwaart, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huster, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katalinic, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Linn, Sabine C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moorthie, SowmiyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pharoah, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spranger, TadeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Delden, Johannes Jozef MartenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Bulcke, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woopen, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-605875
DOI: 10.1159/000517182
Journal or Publication Title: Breast Care
Date: 2022
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1661-3805
Language: English
Faculty: Faculty of Law
Divisions: Faculty of Law > Zivilrecht > Professur für Medizinrecht
Subjects: Law
Uncontrolled Keywords:
KeywordsLanguage
BRCA2 MUTATION CARRIERS; BREAST-CANCER; HEALTH-PROFESSIONALS; FAMILIAL RISK; VISUAL AIDS; GENOMICS; SURVIVAL; WOMEN; COMMUNICATION; INFORMATIONMultiple languages
Oncology; Obstetrics & GynecologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/60587

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