Iacucci, Marietta, Smith, Samuel C. L., Bazarova, Alina, Shivaji, Uday N., Bhandari, Pradeep, Cannatelli, Rosanna, Daperno, Marco, Ferraz, Jose, Goetz, Martin, Gui, Xianyong, Hayee, Bu, De Hertogh, Gert, Lazarev, Mark, Li, Jim, Nardone, Olga M., Parra-Blanco, Adolfo, Pastorelli, Luca, Panaccione, Remo ORCID: 0000-0002-5247-940X, Occhipinti, Vincenzo, Rath, Timo, Tontini, Gian Eugenio, Vieth, Michael, Villanacci, Vincenzo, Zardo, Davide, Bisschops, Raf ORCID: 0000-0002-9994-8226, Kiesslich, Ralf and Ghosh, Subrata ORCID: 0000-0002-1713-7797 (2021). An International Multicenter Real-Life Prospective Study of Electronic Chromoendoscopy Score PICaSSO in Ulcerative Colitis. Gastroenterology, 160 (5). S. 1558 - 1578. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1528-0012

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Abstract

BACKGROUND & AIMS: Endoscopic and histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre (PICaSSO) and other established endoscopic scores against multiple histological indices and prospectively assessed outcomes. METHODS: In this prospective multicenter international study, inflammatory activity was assessed with high- definition and virtual chromoendoscopy in the rectum and sigmoid using the Mayo Endoscopic Score (MES), UC Endoscopic Index of Severity (UCEIS), and PICaSSO. Targeted biopsies were taken for assessment using Robarts Histological Index (RHI), Nancy Histological index (NHI), ECAP (Extent, Chronicity, Activity, Plus score), Geboes, and Villanacci. Followup data were obtained at 6 and 12 months after colonoscopy. RESULTS: A total of 307 patients were recruited. There was strong correlation between PICaSSO and histology scores, significantly superior to correlation coefficients of MES and UCEIS with histology scores. A PICaSSO score of <= 3 detected histologic remission by RHI (<= 3 + absence of neutrophils) with area under the receiver operating characteristic curve (AUROC) 0.90 (95% confidence interval [CI] 0.86-0.94) and NHI (<= 1) AUROC 0.82 (95% CI 0.77-0.87). The interobserver agreement for PICaSSO was 0.88 (95% CI 0.83-0.92). At 6- and 12-months follow-up, PICaSSO score <= 3 predicted better outcomes than PICaSSO >3 (hazard ratio [HR] 0.19 [0.11-0.33] and 0.22 [0.13-0.34], respectively),} as well as PICaSSO 4-8 (HR 0.25 [0.12-0.53] and 0.22 (0.12-0.39), respectively) and similar to histologic remission. CONCLUSION: In this first real-life multicenter study, the PICaSSO score correlated strongly with multiple histological indices. Furthermore, PICaSSO score predicted specified clinical outcomes at 6 and 12 months, similar to histology. Thus, PICaSSO can be a useful endoscopic tool in the therapeutic management of UC.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Iacucci, MariettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Samuel C. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bazarova, AlinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shivaji, Uday N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhandari, PradeepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cannatelli, RosannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daperno, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraz, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goetz, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gui, XianyongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayee, BuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Hertogh, GertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazarev, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, JimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nardone, Olga M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parra-Blanco, AdolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pastorelli, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panaccione, RemoUNSPECIFIEDorcid.org/0000-0002-5247-940XUNSPECIFIED
Occhipinti, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rath, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tontini, Gian EugenioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieth, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villanacci, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zardo, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bisschops, RafUNSPECIFIEDorcid.org/0000-0002-9994-8226UNSPECIFIED
Kiesslich, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghosh, SubrataUNSPECIFIEDorcid.org/0000-0002-1713-7797UNSPECIFIED
URN: urn:nbn:de:hbz:38-605984
DOI: 10.1053/j.gastro.2020.12.024
Journal or Publication Title: Gastroenterology
Volume: 160
Number: 5
Page Range: S. 1558 - 1578
Date: 2021
Publisher: W B SAUNDERS CO-ELSEVIER INC
Place of Publication: PHILADELPHIA
ISSN: 1528-0012
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLINICAL RELAPSE; ENDOSCOPIC INDEX; INFLAMMATION; COLONOSCOPY; RELIABILITY; VALIDATION; INFLIXIMAB; REMISSION; OUTCOMESMultiple languages
Gastroenterology & HepatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60598

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