Baertsch, Marc-Andrea, Mai, Elias K., Hielscher, Thomas, Bertsch, Uta, Salwender, Hans J., Munder, Markus, Fuhrmann, Stephan ORCID: 0000-0002-7785-2565, Duehrsen, Ulrich, Brossart, Peter, Neben, Kai, Schlenzka, Jana, Kunz, Christina, Raab, Marc S., Hillengass, Jens, Jauch, Anna, Seckinger, Anja, Hose, Dirk, Luntz, Steffen, Sonneveld, Pieter, Lokhorst, Henk, Martin, Hans, Goerner, Martin, Hoffmann, Martin, Lindemann, Hans-Walter, Bernhard, Helga, Blau, Igor W., Scheid, Christof, Besemer, Britta, Weisel, Katja C., Haenel, Mathias, Duerig, Jan and Goldschmidt, Hartmut (2021). Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma. Blood Cancer J., 11 (1). LONDON: SPRINGERNATURE. ISSN 2044-5385

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Abstract

Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents in clinical trials. We retrospectively compared bortezomib (BTZ; n=138) or LEN (n=183) MT from two subsequent GMMG phase III trials. All patients received three cycles of BTZ-based triplet induction and post-ASCT MT. BTZ MT (1.3mg/m(2) i.v.) was administered every 2 weeks for 2 years. LEN MT included two consolidation cycles (25mg p.o., days 1-21 of 28 day cycles) followed by 10-15mg/day for 2 years. The BTZ cohort more frequently received tandem ASCT (91% vs. 33%) due to different tandem ASCT strategies. In the LEN and BTZ cohort, 43% and 46% of patients completed 2 years of MT as intended (p=0.57). Progression-free survival (PFS; HR=0.83, p=0.18) and overall survival (OS; HR=0.70, p=0.15) did not differ significantly with LEN vs. BTZ MT. Patients with <nCR after first ASCT were assigned tandem ASCT in both trials. In patients with <nCR and tandem ASCT (LEN: n=54 vs. BTZ: n=84), LEN MT significantly improved PFS (HR=0.61, p=0.04) but not OS (HR=0.46, p=0.09). In conclusion, the significant PFS benefit after eliminating the impact of different tandem ASCT rates supports the current standard of LEN MT after ASCT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Baertsch, Marc-AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mai, Elias K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hielscher, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bertsch, UtaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salwender, Hans J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munder, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuhrmann, StephanUNSPECIFIEDorcid.org/0000-0002-7785-2565UNSPECIFIED
Duehrsen, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brossart, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neben, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlenzka, JanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunz, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raab, Marc S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillengass, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jauch, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seckinger, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hose, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luntz, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sonneveld, PieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lokhorst, HenkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goerner, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindemann, Hans-WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernhard, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blau, Igor W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besemer, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weisel, Katja C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haenel, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duerig, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldschmidt, HartmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606220
DOI: 10.1038/s41408-020-00390-3
Journal or Publication Title: Blood Cancer J.
Volume: 11
Number: 1
Date: 2021
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 2044-5385
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
THERAPY; DEXAMETHASONE; SINGLE; GUIDELINES; INDUCTION; VCDMultiple languages
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60622

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