Lesueur, Fabienne, Easton, Douglas F., Renault, Anne-Laure, Tavtigian, Sean, V, Bernstein, Jonine L., Kote-Jarai, Zsofia, Eeles, Rosalind A., Plaseska-Karanfia, Dijana, Feliubadalo, Lidia ORCID: 0000-0002-1736-0112, Arun, Banu, Herold, Natalie, Versmold, Beatrix, Schmutzler, Rita Katharina, Nguyen-Dumont, Tu, Southey, Melissa C., Dorling, Leila, Dunning, Alison M., Ghiorzo, Paola, Dalmasso, Bruna Samia, Cavaciuti, Eve, Le Gal, Dorothee, Roberts, Nicholas J., Dominguez-Valentin, Mev, Rookus, Matti, Taylor, Alexander M. R., Goldstein, Alisa M., Goldgar, David E., Stoppa-Lyonnet, Dominique and Andrieu, Nadine . First international workshop of the ATM and cancer risk group (4-5 December 2019). Fam. Cancer. DORDRECHT: SPRINGER. ISSN 1573-7292

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Abstract

The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated by the fact that germline ATM pathogenic variants have been found to be associated with different cancer types. However, due to the lack of precise age-, sex-, and site-specific risk estimates, no consensus on management guidelines for variant carriers exists, and the clinical utility of ATM variant testing is uncertain. The meeting brought together epidemiologists, geneticists, biologists and clinicians to review current knowledge and on-going challenges related to ATM and cancer risk. This report summarizes the meeting sessions content that covered the latest results in family-based and population-based studies, the importance of accurate variant classification, the effect of radiation exposures for ATM variant carriers, and the characteristics of ATM-deficient tumors. The report concludes that ATM variant carriers outside of the context of Ataxia-Telangiectasia may benefit from effective cancer risk management and therapeutic strategies and that efforts to set up large-scale studies in the international framework to achieve this goal are necessary.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lesueur, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renault, Anne-LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tavtigian, Sean, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bernstein, Jonine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kote-Jarai, ZsofiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, Rosalind A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plaseska-Karanfia, DijanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feliubadalo, LidiaUNSPECIFIEDorcid.org/0000-0002-1736-0112UNSPECIFIED
Arun, BanuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herold, NatalieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Versmold, BeatrixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmutzler, Rita KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nguyen-Dumont, TuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, Melissa C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorling, LeilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunning, Alison M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghiorzo, PaolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dalmasso, Bruna SamiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavaciuti, EveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Gal, DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roberts, Nicholas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dominguez-Valentin, MevUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rookus, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylor, Alexander M. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldstein, Alisa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrieu, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606408
DOI: 10.1007/s10689-021-00248-y
Journal or Publication Title: Fam. Cancer
Publisher: SPRINGER
Place of Publication: DORDRECHT
ISSN: 1573-7292
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ATAXIA-TELANGIECTASIA; BREAST-CANCER; CLINICAL-SIGNIFICANCE; HEREDITARY BREAST; GENE; MUTATIONS; HETEROZYGOTES; PANEL; VARIANTS; FAMILIESMultiple languages
Oncology; Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60640

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