Marchant, Natalie L., Barnhofer, Thorsten, Coueron, Roxane, Wirth, Miranka, Lutz, Antoine, Arenaza-Urquijo, Eider M., Collette, Fabienne, Poisnel, Geraldine, Demnitz-King, Harriet, Schild, Ann-Katrin, Coll-Padros, Nina ORCID: 0000-0002-9282-6701, Delphin-Combe, Floriane, Whitfield, Tim, Schlosser, Marco ORCID: 0000-0002-0634-0749, Gonneaud, Julie ORCID: 0000-0003-0566-5581, Asselineau, Julien, Walker, Zuzana, Krolak-Salmon, Pierre, Molinuevo, Jose Luis, Frison, Eric ORCID: 0000-0001-5844-1886, Chetelat, Gael, Jessen, Frank and Klimecki, Olga M. (2021). Effects of a Mindfulness-Based Intervention versus Health Self-Management on Subclinical Anxiety in Older Adults with Subjective Cognitive Decline: The SCD-Well Randomized Superiority Trial. Psychother. Psychosom., 90 (5). S. 341 - 351. BASEL: KARGER. ISSN 1423-0348

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Abstract

Introduction: Older adults experiencing subjective cognitive decline (SCD) have a heightened risk of developing dementia and frequently experience subclinical anxiety, which is itself associated with dementia risk. Objective: To understand whether subclinical anxiety symptoms in SCD can be reduced through behavioral interventions. Methods: SCD-Well is a randomized controlled trial designed to determine whether an 8-week mindfulness-based intervention (caring mindfulness-based approach for seniors; CMBAS) is superior to a structurally matched health self-management program (HSMP) in reducing subclinical anxiety. Participants were recruited from memory clinics at 4 European sites. The primary outcome was change in anxiety symptoms (trait subscale of the State-Trait Anxiety Inventory; trait-STAI) from pre- to postintervention. Secondary outcomes included a change in state anxiety and depression symptoms postintervention and 6 months postrandomization (follow-up). Results: One hundred forty-seven participants (mean [SD] age: 72.7 [6.9] years; 64.6% women; CMBAS, n = 73; HSMP, n = 74) were included in the intention-to-treat analysis. There was no difference in trait-STAI between groups postintervention (adjusted change difference: -1.25 points; 95% CI -4.76 to 2.25) or at follow-up (adjusted change difference: -0.43 points; 95% CI -2.92 to 2.07). Trait-STAI decreased postintervention in both groups (CMBAS: -3.43 points; 95% CI -5.27 to -1.59; HSMP: -2.29 points; 95% CI -4.14 to -0.44) and reductions were maintained at follow-up. No between-group differences were observed for change in state anxiety or depression symptoms. Conclusions: A time-limited mindfulness intervention is not superior to health self-management in reducing subclinical anxiety symptoms in SCD. The sustained reduction observed across both groups suggests that subclinical anxiety symptoms in SCD are modifiable. ClinicalTrials.gov identifier: NCT03005652.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Marchant, Natalie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barnhofer, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coueron, RoxaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirth, MirankaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lutz, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arenaza-Urquijo, Eider M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Collette, FabienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poisnel, GeraldineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demnitz-King, HarrietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schild, Ann-KatrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coll-Padros, NinaUNSPECIFIEDorcid.org/0000-0002-9282-6701UNSPECIFIED
Delphin-Combe, FlorianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whitfield, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlosser, MarcoUNSPECIFIEDorcid.org/0000-0002-0634-0749UNSPECIFIED
Gonneaud, JulieUNSPECIFIEDorcid.org/0000-0003-0566-5581UNSPECIFIED
Asselineau, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, ZuzanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krolak-Salmon, PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinuevo, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frison, EricUNSPECIFIEDorcid.org/0000-0001-5844-1886UNSPECIFIED
Chetelat, GaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimecki, Olga M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-606558
DOI: 10.1159/000515669
Journal or Publication Title: Psychother. Psychosom.
Volume: 90
Number: 5
Page Range: S. 341 - 351
Date: 2021
Publisher: KARGER
Place of Publication: BASEL
ISSN: 1423-0348
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS-DISEASE; TRAIT ANXIETY; STRESS REDUCTION; THERAPY; METAANALYSIS; SYMPTOMS; DEMENTIA; CRITERIA; RISKMultiple languages
Psychiatry; PsychologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60655

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