de Pablo, Gonzalo Salazar, Solmi, Marco, Vaquerizo-Serrano, Julio, Radua, Joaquim ORCID: 0000-0003-1240-5438, Passina, Anastassia, Mosillo, Pierluca, Correll, Christoph U., Borgwardt, Stefan ORCID: 0000-0002-5792-3987, Galderisi, Silvana, Bechdolf, Andreas, Pfennig, Andrea, Bauer, Michael, Kessing, Lars Vedel, van Amelsvoort, Therese, Nieman, Dorien H., Domschke, Katharina, Krebs, Marie-Odile ORCID: 0000-0002-4715-9890, Sand, Michael, Vieta, Eduard ORCID: 0000-0002-0548-0053, McGuire, Philip, Arango, Celso ORCID: 0000-0003-3382-4754, Il Shin, Jae and Fusar-Poli, Paolo ORCID: 0000-0003-3582-6788 (2021). Primary prevention of depression: An umbrella review of controlled interventions. J. Affect. Disord., 294. S. 957 - 971. AMSTERDAM: ELSEVIER. ISSN 1573-2517

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Abstract

Background: Primary prevention has the potential to modify the course of depression, but the consistency and magnitude of this effect are currently undetermined. Methods: PRISMA and RIGHT compliant (PROSPERO:CRD42020179659) systematic meta-review, PubMed/ Web of Science, up to June 2020. Meta-analyses of controlled interventions for the primary prevention of depressive symptoms [effect measures: standardized mean difference (SMD)] or depressive disorders [effect measure: relative risk (RR)] were carried out. Results were stratified by: (i) age range; (ii) target population (general and/or at-risk); (iii) intervention type. Quality (assessed with AMSTAR/AMSTAR-PLUS content) and credibility (graded as high/moderate/low) were assessed. USPSTF grading system was used for recommendations. Results: Forty-six meta-analyses (k=928 individual studies, n=286,429 individuals, mean age=22.4 years, 81.1% female) were included. Effect sizes were: SMD=0.08-0.53; for depressive symptoms; RR=0.90-0.28 for depressive disorders. Sensitivity analyses including only RCTs did not impact the findings. AMSTAR median=9 (IQR=8-9); AMSTAR-PLUS content median=4.25 (IQR=4-5). Credibility of the evidence was insufficient/low in 43 (93.5%) meta-analyses, moderate in two (4.3%), and high in one (2.2%): reduction of depressive symptoms using psychosocial interventions for young adults only, and a combination of psychological and educational interventions in primary care had moderate credibility; preventive administration of selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in individuals with a stroke had high credibility. Limitations: Intervention heterogeneity and lack of long-term efficacy evaluation. Conclusions: Primary preventive interventions for depression might be effective. Among them, clinicians may offer SSRIs post-stroke to prevent depressive disorders, and psychosocial interventions for children/adolescents/ young adults with risk factors or during the prenatal/perinatal period.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
de Pablo, Gonzalo SalazarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Solmi, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaquerizo-Serrano, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radua, JoaquimUNSPECIFIEDorcid.org/0000-0003-1240-5438UNSPECIFIED
Passina, AnastassiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosillo, PierlucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Correll, Christoph U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borgwardt, StefanUNSPECIFIEDorcid.org/0000-0002-5792-3987UNSPECIFIED
Galderisi, SilvanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfennig, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kessing, Lars VedelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Amelsvoort, ThereseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nieman, Dorien H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domschke, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krebs, Marie-OdileUNSPECIFIEDorcid.org/0000-0002-4715-9890UNSPECIFIED
Sand, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieta, EduardUNSPECIFIEDorcid.org/0000-0002-0548-0053UNSPECIFIED
McGuire, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arango, CelsoUNSPECIFIEDorcid.org/0000-0003-3382-4754UNSPECIFIED
Il Shin, JaeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fusar-Poli, PaoloUNSPECIFIEDorcid.org/0000-0003-3582-6788UNSPECIFIED
URN: urn:nbn:de:hbz:38-607307
DOI: 10.1016/j.jad.2021.07.101
Journal or Publication Title: J. Affect. Disord.
Volume: 294
Page Range: S. 957 - 971
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2517
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EDUCATIONAL INTERVENTIONS; POSTSTROKE DEPRESSION; CONTROLLED-TRIALS; MENTAL-HEALTH; YOUNG-PEOPLE; HEPATITIS-C; METAANALYSIS; CHILDREN; ANXIETY; PSYCHOTHERAPYMultiple languages
Clinical Neurology; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60730

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