Baunwall, Simon Mark Dahl, Terveer, Elisabeth M., Dahlerup, Jens Frederik, Erikstrup, Christian ORCID: 0000-0001-6551-6647, Arkkila, Perttu, Vehreschild, Maria J. G. T., Ianiro, Gianluca, Gasbarrini, Antonio ORCID: 0000-0003-4863-6924, Sokol, Harry, Kump, Patrizia K., Satokari, Reetta, De Looze, Danny, Vermeire, Severine ORCID: 0000-0001-9942-3019, Nakov, Radislav, Brezina, Jan, Helms, Morten, Kjeldsen, Jens ORCID: 0000-0001-8148-6572, Rode, Anne A., Kousgaard, Sabrina Just ORCID: 0000-0002-2394-7104, Alric, Laurent, Trang-Poisson, Caroline, Scanzi, Julien, Link, Alexander, Stallmach, Andreas, Kupcinskas, Juozas, Johnsen, Peter Holger, Garborg, Kjetil, Rodriguez, Eugenia Sanchez, Serrander, Lena, Brummer, Robert J., Galperine, Katerina Tatiana, Goldenberg, Simon D., Mullish, Benjamin H., Williams, Horace Rt, Iqbal, Tariq H., Ponsioen, Cyriel, Kuijper, Ed J., Cammarota, Giovanni ORCID: 0000-0002-3626-6148, Keller, Josbert J. and Hvas, Christian Lodberg (2021). The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey. Lancet Reg. Health-Eur., 9. AMSTERDAM: ELSEVIER. ISSN 2666-7762

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Abstract

Background: Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe. Methods: We invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT. Findings: In 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10.64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0.3%) unaccounted for. Adjusted to population size, 0.257 per 100,000 population received FMT for CDI and 0-189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-8,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres. Interpretation: FMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need. (C) 2021 The Authors. Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Baunwall, Simon Mark DahlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Terveer, Elisabeth M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahlerup, Jens FrederikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erikstrup, ChristianUNSPECIFIEDorcid.org/0000-0001-6551-6647UNSPECIFIED
Arkkila, PerttuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ianiro, GianlucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gasbarrini, AntonioUNSPECIFIEDorcid.org/0000-0003-4863-6924UNSPECIFIED
Sokol, HarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kump, Patrizia K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Satokari, ReettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Looze, DannyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vermeire, SeverineUNSPECIFIEDorcid.org/0000-0001-9942-3019UNSPECIFIED
Nakov, RadislavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brezina, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helms, MortenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kjeldsen, JensUNSPECIFIEDorcid.org/0000-0001-8148-6572UNSPECIFIED
Rode, Anne A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kousgaard, Sabrina JustUNSPECIFIEDorcid.org/0000-0002-2394-7104UNSPECIFIED
Alric, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trang-Poisson, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scanzi, JulienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Link, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stallmach, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kupcinskas, JuozasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johnsen, Peter HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garborg, KjetilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, Eugenia SanchezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serrander, LenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brummer, Robert J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galperine, Katerina TatianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldenberg, Simon D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullish, Benjamin H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Horace RtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iqbal, Tariq H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ponsioen, CyrielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuijper, Ed J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammarota, GiovanniUNSPECIFIEDorcid.org/0000-0002-3626-6148UNSPECIFIED
Keller, Josbert J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hvas, Christian LodbergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-607998
DOI: 10.1016/j.lanepe.2021.100181
Journal or Publication Title: Lancet Reg. Health-Eur.
Volume: 9
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 2666-7762
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CLOSTRIDIUM-DIFFICILE INFECTION; RECURRENT; SOCIETYMultiple languages
Health Care Sciences & Services; Public, Environmental & Occupational HealthMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60799

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