Naehrlich, Lutz, Orenti, Annalisa ORCID: 0000-0002-0932-2757, Dunlevy, Fiona, Kasmi, Irena, Harutyunyan, Satenik, Pfleger, Andreas, Keegan, Svetlana, Daneau, Geraldine, Petrova, Guergana ORCID: 0000-0001-8168-742X, Tjesic-Drinkovic, Duska, Yiallouros, Panayioti, Bilkova, Alena, Olesen, Hanne Vebert, Burgel, Pierre-Regis, Parulava, Tsitsino, Diamantea, Filia, Parniczky, Andrea, McKone, Edward F., Mei-Zahav, Meir, Salvatore, Marco, Colombo, Carla, Aleksejeva, Elina, Malakauskas, Kestutis, Schlesser, Marc, Fustik, Stojka, Turcu, Oxana ORCID: 0000-0002-2213-9084, Zomer-van Ommen, Domenique, Wathne, Anita Senstad, Wozniacki, Lukasz, Pereira, Luisa, Pop, Liviu, Kashirskaya, Nataliya, Rodic, Milan, Kayserova, Hana, Krivecs, Uro, Mondejar-Lopez, Pedro, de Monsterol, Isabelle, Dogru, Deniz, Makukh, Halyn, Cosgriff, Rebecca, van Koningsbruggen-Rietschel, Silke, Jung, Andreas, Bobrovnichy, Vladimir, Bambir, Ivan, Vukic, Andrea Dugac, Drevinek, Pavel, Macek, Milan, Jr., Corvol, Harriet ORCID: 0000-0002-7026-7523, Lemonnier-Videau, Lydie, Hatziagorou, Elpis, Fletcher, Godfrey, Padoan, Rita, Gulmans, Vincent, Bakkeheim, Egil, Kondratyeva, Elena, Amelina, Elena, Zhekaite, Elena, Simonova, Olga, Pastor-Vivero, Maria Dolores, Lindblad, Anders, Gokdemir, Yasemin, Pekcan, Sevgi, Brownlee, Keith, McClenaghan, Elliot ORCID: 0000-0002-0902-6122, Carr, Siobhan, Lammertyn, Elise, Zolin, Anna, Fox, Alice, Krasnyk, Marko and Van Rens, Jacqui (2021). Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020. J. Cyst. Fibros, 20 (4). S. 566 - 578. AMSTERDAM: ELSEVIER. ISSN 1873-5010

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Abstract

Background: Viral infections can cause significant morbidity in cystic fibrosis (CF). The current Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic could therefore have a serious impact on the health of people with CF (pwCF). Methods: We used the 38-country European Cystic Fibrosis Society Patient Registry (ECFSPR) to collect case data about pwCF and SARS-CoV-2 infection. Results: Up to 30 June 2020, 16 countries reported 130 SARS-CoV-2 cases in people with CF, yielding an incidence of 2.70/10 0 0 pwCF. Incidence was higher in lung-transplanted patients (n = 23) versus non transplanted patients (n = 107) (8.43 versus 2.36 cases/10 0 0). Incidence was higher in pwCF versus the age-matched general population in the age groups < 15, 15-24, and 25-49 years (p < 0.001), with similar trends for pwCF with and without lung transplant. Compared to the general population, pwCF (regardless of transplantation status) had significantly higher rates of admission to hospital for all age groups with available data, and higher rates of intensive care, although not statistically significant. Most pwCF recovered (96.2%), however 5 died, of whom 3 were lung transplant recipients. The case fatality rate for pwCF (3.85%, 95% CI: 1.26-8.75) was non-significantly lower than that of the general population (7.46%; p = 0.133). Conclusions: SARS-CoV-2 infection can result in severe illness and death for pwCF, even for younger patients and especially for lung transplant recipients. PwCF should continue to shield from infection and should be prioritized for vaccination. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Naehrlich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orenti, AnnalisaUNSPECIFIEDorcid.org/0000-0002-0932-2757UNSPECIFIED
Dunlevy, FionaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasmi, IrenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harutyunyan, SatenikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfleger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keegan, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daneau, GeraldineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petrova, GuerganaUNSPECIFIEDorcid.org/0000-0001-8168-742XUNSPECIFIED
Tjesic-Drinkovic, DuskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yiallouros, PanayiotiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilkova, AlenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olesen, Hanne VebertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgel, Pierre-RegisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parulava, TsitsinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diamantea, FiliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parniczky, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McKone, Edward F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mei-Zahav, MeirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salvatore, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colombo, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aleksejeva, ElinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malakauskas, KestutisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlesser, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fustik, StojkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turcu, OxanaUNSPECIFIEDorcid.org/0000-0002-2213-9084UNSPECIFIED
Zomer-van Ommen, DomeniqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wathne, Anita SenstadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wozniacki, LukaszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pereira, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pop, LiviuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kashirskaya, NataliyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodic, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kayserova, HanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krivecs, UroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mondejar-Lopez, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Monsterol, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dogru, DenizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makukh, HalynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cosgriff, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Koningsbruggen-Rietschel, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bobrovnichy, VladimirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bambir, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vukic, Andrea DugacUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drevinek, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Macek, Milan, Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corvol, HarrietUNSPECIFIEDorcid.org/0000-0002-7026-7523UNSPECIFIED
Lemonnier-Videau, LydieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatziagorou, ElpisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fletcher, GodfreyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Padoan, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gulmans, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bakkeheim, EgilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kondratyeva, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amelina, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zhekaite, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simonova, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pastor-Vivero, Maria DoloresUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lindblad, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gokdemir, YaseminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pekcan, SevgiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brownlee, KeithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McClenaghan, ElliotUNSPECIFIEDorcid.org/0000-0002-0902-6122UNSPECIFIED
Carr, SiobhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lammertyn, EliseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zolin, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, AliceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krasnyk, MarkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Rens, JacquiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608161
DOI: 10.1016/j.jcf.2021.03.017
Journal or Publication Title: J. Cyst. Fibros
Volume: 20
Number: 4
Page Range: S. 566 - 578
Date: 2021
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1873-5010
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMPACTMultiple languages
Respiratory SystemMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60816

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