Ali, Myzoon, VandenBerg, Kathryn, Williams, Linda J., Williams, Louise R., Abo, Masahiro, Becker, Frank ORCID: 0000-0002-0857-0628, Bowen, Audrey ORCID: 0000-0003-4075-1215, Brandenburg, Caitlin, Breitenstein, Caterina, Bruehl, Stefanie ORCID: 0000-0003-4826-1990, Copland, David A., Cranfill, Tamara B., Di Pietro-Bachmann, Marie, Enderby, Pamela ORCID: 0000-0002-4371-9053, Fillingham, Joanne, Galli, Federica Lucia, Gandolfi, Marialuisa ORCID: 0000-0002-0877-4807, Glize, Bertrand, Godecke, Erin, Hawkins, Neil, Hilari, Katerina ORCID: 0000-0003-2091-4849, Hinckley, Jacqueline, Horton, Simon, Howard, David, Jaecks, Petra, Jefferies, Elizabeth, Jesus, Luis M. T., Kambanaros, Maria, Kang, Eun Kyoung, Khedr, Eman M., Kong, Anthony Pak-Hin, Kukkonen, Tarja, Laganaro, Marina, Ralph, Matthew A. Lambon, Laska, Ann Charlotte, Leemann, Beatrice, Leff, Alexander P., Lima, Roxele R., Lorenz, Antje, Mac Whinney, Brian, Marshall, Rebecca Shisler, Meinzer, Marcus, Nilipour, Reza, Noe, Enrique, Paik, Nam-Jong, Palmer, Rebecca, Papathanasiou, Ilias, Patricio, Brigida F., Martins, Isabel Pavao, Price, Cathy, Jakovac, Tatjana Prizl, Rochon, Elizabeth, Rose, Miranda L., Rosso, Charlotte, Rubi-Fessen, Ilona ORCID: 0000-0002-9775-3812, Ruiter, Marina B. ORCID: 0000-0001-6147-5235, Snell, Claerwen, Stahl, Benjamin, Szaflarski, Jerzy P., Thomas, Shirley A., Van De Sandt-Koenderman, Mieke, van der Meulen, Ineke, Visch-Brink, Evy, Worrall, Linda, Wright, Heather Harris and Brady, Marian C. (2021). Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis. Stroke, 52 (5). S. 1778 - 1788. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1524-4628

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Abstract

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants' age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4-165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3-26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0-20.9], +6.1 correct on AAT Token Test [CI, 3.2-8.9]; +9.3 Boston Naming Test points [CI, 4.7-13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5-1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9-24.4]; +5.3 correct on AAT Token Test [CI, 1.7-8.8]; +11.1 Boston Naming Test points [CI, 5.7-16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7-1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. Conclusions: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Ali, MyzoonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
VandenBerg, KathrynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Linda J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, Louise R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abo, MasahiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, FrankUNSPECIFIEDorcid.org/0000-0002-0857-0628UNSPECIFIED
Bowen, AudreyUNSPECIFIEDorcid.org/0000-0003-4075-1215UNSPECIFIED
Brandenburg, CaitlinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Breitenstein, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruehl, StefanieUNSPECIFIEDorcid.org/0000-0003-4826-1990UNSPECIFIED
Copland, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cranfill, Tamara B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Pietro-Bachmann, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Enderby, PamelaUNSPECIFIEDorcid.org/0000-0002-4371-9053UNSPECIFIED
Fillingham, JoanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galli, Federica LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gandolfi, MarialuisaUNSPECIFIEDorcid.org/0000-0002-0877-4807UNSPECIFIED
Glize, BertrandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Godecke, ErinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hawkins, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hilari, KaterinaUNSPECIFIEDorcid.org/0000-0003-2091-4849UNSPECIFIED
Hinckley, JacquelineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horton, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Howard, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaecks, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jefferies, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jesus, Luis M. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambanaros, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, Eun KyoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khedr, Eman M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kong, Anthony Pak-HinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kukkonen, TarjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laganaro, MarinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ralph, Matthew A. LambonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laska, Ann CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leemann, BeatriceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leff, Alexander P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lima, Roxele R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenz, AntjeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mac Whinney, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marshall, Rebecca ShislerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meinzer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilipour, RezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noe, EnriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paik, Nam-JongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palmer, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papathanasiou, IliasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patricio, Brigida F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martins, Isabel PavaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Price, CathyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakovac, Tatjana PrizlUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rochon, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rose, Miranda L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosso, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rubi-Fessen, IlonaUNSPECIFIEDorcid.org/0000-0002-9775-3812UNSPECIFIED
Ruiter, Marina B.UNSPECIFIEDorcid.org/0000-0001-6147-5235UNSPECIFIED
Snell, ClaerwenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stahl, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szaflarski, Jerzy P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomas, Shirley A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van De Sandt-Koenderman, MiekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Meulen, InekeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Visch-Brink, EvyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worrall, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wright, Heather HarrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brady, Marian C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-608176
DOI: 10.1161/STROKEAHA.120.031162
Journal or Publication Title: Stroke
Volume: 52
Number: 5
Page Range: S. 1778 - 1788
Date: 2021
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1524-4628
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RANDOMIZED CONTROLLED-TRIAL; STROKE PATIENTS; THERAPY; REHABILITATION; COMMUNICATION; PROGNOSIS; BURDENMultiple languages
Clinical Neurology; Peripheral Vascular DiseaseMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/60817

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