Universität zu Köln

Jacobs, Lianne J. H. C. and Riemer, Jan (2023). Maintenance of small molecule redox homeostasis in mitochondria. FEBS Lett., 597 (2). S. 205 - 224. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

Compartmentalisation of eukaryotic cells enables fundamental otherwise often incompatible cellular processes. Establishment and maintenance of distinct compartments in the cell relies not only on proteins, lipids and metabolites but also on small redox molecules. In particular, small redox molecules such as glutathione, NAD(P)H and hydrogen peroxide (H2O2) cooperate with protein partners in dedicated machineries to establish specific subcellular redox compartments with conditions that enable oxidative protein folding and redox signalling. Dysregulated redox homeostasis has been directly linked with a number of diseases including cancer, neurological disorders, cardiovascular diseases, obesity, metabolic diseases and ageing. In this review, we will summarise mechanisms regulating establishment and maintenance of redox homeostasis in the mitochondrial subcompartments of mammalian cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jacobs, Lianne J. H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riemer, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-659784
DOI:	10.1002/1873-3468.14485
Journal or Publication Title:	FEBS Lett.
Volume:	597
Number:	2
Page Range:	S. 205 - 224
Date:	2023
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DISULFIDE RELAY SYSTEM; IRON-SULFUR PROTEIN; GLUTATHIONE-S-TRANSFERASE; CYTOCHROME C REDUCTASE; INTERMEMBRANE SPACE; SUPEROXIDE-PRODUCTION; HYDROGEN-PEROXIDE; ELECTRON-TRANSFER; GLUTAREDOXIN 2; 2-OXOGLUTARATE CARRIERS Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/65978