Universität zu Köln

Celik, Erkan ORCID: 0000-0001-5687-7707, Nelles, Christian, Kottlors, Jonathan, Fervers, Philipp, Goertz, Lukas, dos Santos, Daniel Pinto, Achenbach, Tobias, Maintz, David and Persigehl, Thorsten (2022). Quantitative determination of pulmonary emphysema in follow-up LD-CTs of patients with COVID-19 infection. PLoS One, 17 (2). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Purpose To evaluate the association between the coronavirus disease 2019 (COVID-19) and post-inflammatory emphysematous lung alterations on follow-up low-dose CT scans. Methods Consecutive patients with proven COVID-19 infection and a follow-up CT were retrospectively reviewed. The severity of pulmonary involvement was classified as mild, moderate and severe. Total lung volume, emphysema volume and the ratio of emphysema/-to-lung volume were quantified semi-automatically and compared inter-individually between initial and follow-up CT and to a control group of healthy, age- and sex-matched patients. Lung density was further assessed by drawing circular regions of interest (ROIs) into non-affected regions of the upper lobes. Results A total of 32 individuals (mean age: 64 +/- 13 years, 12 females) with at least one follow-up CT (mean: 52 +/- 66 days, range: 5-259) were included. In the overall cohort, total lung volume, emphysema volume and the ratio of lung-to-emphysema volume did not differ significantly between the initial and follow-up scans. In the subgroup of COVID-19 patients with > 30 days of follow-up, the emphysema volume was significantly larger as compared to the subgroup with a follow-up < 30 days (p = 0.045). Manually measured single ROls generally yielded lower attenuation values prior to COVID-19 pneumonia, but the difference was not significant between groups (all p > 0.05). Conclusion COVID-19 patients with a follow-up CT >30 days showed significant emphysematous lung alterations. These findings may help to explain the long-term effect of COVID-19 on pulmonary function and warrant validation by further studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Celik, Erkan UNSPECIFIED orcid.org/0000-0001-5687-7707 UNSPECIFIED Nelles, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kottlors, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Fervers, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED dos Santos, Daniel Pinto UNSPECIFIED UNSPECIFIED UNSPECIFIED Achenbach, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662357
DOI:	10.1371/journal.pone.0263261
Journal or Publication Title:	PLoS One
Volume:	17
Number:	2
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66235