Universität zu Köln

Oezer, Orlando, Mestanoglu, Mert ORCID: 0000-0002-7984-5959, Howaldt, Antonia ORCID: 0000-0001-7596-8073, Clahsen, Thomas, Schiller, Petra ORCID: 0000-0002-9957-1465, Siebelmann, Sebastian, Reinking, Niklas, Cursiefen, Claus, Bachmann, Bjoern and Matthaei, Mario (2022). Correlation of Clinical Fibrillar Layer Detection and Corneal Thickness in Advanced Fuchs Endothelial Corneal Dystrophy. J. Clin. Med., 11 (10). BASEL: MDPI. ISSN 2077-0383

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Abstract

Central subendothelial geographic deposits are formed as a fibrillar layer (FL) in advanced Fuchs endothelial corneal dystrophy (FECD). Previous studies demonstrated a significant decrease in corneal endothelial cell (CEC) density and an increase in focal corneal backscatter in the FL area. The present study investigated the association of the FL with edema formation and its localization. Patients (n = 96) presenting for Descemet membrane endothelial keratoplasty (DMEK) for advanced FECD were included. Slit-lamp biomicroscopy with FECD grading was followed by Scheimpflug imaging with en face backscatter analysis and pachymetric analysis. FL dimensions were measured, and correlation with pachymetric values was performed. An FL was detected in 74% of all eyes (n = 71). Pachymetric values in FL-positive versus FL-negative eyes were for corneal thickness at the apex (ACT) 614 +/- 52 mu m and 575 +/- 46 mu m (p = 0.001), for peripheral corneal thickness at 1 mm (PCT1mm) 616 +/- 50 mu m and 580 +/- 44 mu m (p = 0.002), for PCT2mm 625 +/- 48 mu m and 599 +/- 41 mu m (p = 0.017), for PCT3mm 651 +/- 46 mu m and 635 +/- 40 mu m (p = 0.128) and for PCT4mm 695 +/- 52 mu m and 686 +/- 43 mu m (p = 0.435), respectively. Correlation analysis indicated a weak correlation for the FL maximum vertical caliper diameter with ACT and PCT1mm values but no further relevant correlations. In FL-positive eyes, increased focal corneal backscatter and increased corneal thickness showed primarily central and inferotemporal localization. In conclusion, Scheimpflug imaging shows an association of the FL with increased corneal thickness in advanced FECD and shows localization of the FL and increased corneal thickness in the central and inferotemporal region. This may provide important information for progression assessment and therapeutic decision making in FECD patients in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Oezer, Orlando UNSPECIFIED UNSPECIFIED UNSPECIFIED Mestanoglu, Mert UNSPECIFIED orcid.org/0000-0002-7984-5959 UNSPECIFIED Howaldt, Antonia UNSPECIFIED orcid.org/0000-0001-7596-8073 UNSPECIFIED Clahsen, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiller, Petra UNSPECIFIED orcid.org/0000-0002-9957-1465 UNSPECIFIED Siebelmann, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinking, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662639
DOI:	10.3390/jcm11102815
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	10
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DESCEMETS-MEMBRANE; DENSITOMETRY; TRANSPLANTATION; INHIBITOR; IMAGE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66263