Universität zu Köln

Domroese, Christian Markus, Wieland, Ulrike, Pilch, Henryk, Einzmann, Thomas, Schoemig-Markiefka, Birgid, Mallmann, Peter, Silling, Steffi and Mallmann, Michael Rudolf (2022). Cervical Intraepithelial Neoplasia 3 (Cervical Intraepithelial Neoplasia 3/High-Grade Squamous Intraepithelial Lesion) in Human Papillomavirus-Vaccinated Women-Results From a Tertiary Referral Center. J. Low. Genit. Tract. Dis., 26 (2). S. 122 - 127. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1526-0976

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Abstract

Objective: High-grade cervical intraepithelial neoplasia (CIN 3) still develops in some vaccinated women despite established effectiveness of prophylactic human papillomavirus (HPV) vaccination. The purpose of this study was to define characteristics of women with CIN 3 after HPV vaccination referred to a gynecological dysplasia unit. Materials and Methods: Retrospective analysis of HPV-vaccinated women with CIN 3 in a single German center. Between July 2018 and September 2020, 791 women were referred to our university hospital-based dysplasia unit for colposcopic evaluation of abnormal cytological findings. Human papillomavirus vaccination status was retrieved. Human papillomavirus typing was performed in lesional biopsies and cervical swabs. Results: Nine women were identified who had previously been vaccinated with the quadrivalentHPV vaccine (Q-HPV) andwere diagnosedwith histologically confirmed CIN 3/high-grade squamous intraepithelial lesion. The Q-HPV had been administered between 12 and 28 years of age and 1-13 years before CIN 3 diagnosis. Nine different high-risk (HR)-HPV types were found in the CIN 3 biopsies, 6 monoinfections (twice HPV 16, once HPV 18, HPV 31, HPV 52, HPV 58, respectively) and 3 dual infections (HPV 33 + 52, HPV 51 + 52, HPV 53 + 66). Seven of these 9 HR-HPV types are not covered by Q-HPV, but only 2 CIN 3 lesions carried HR-HPV types not included in the nonavalent HPV vaccine. Conclusions: It is important to implement vaccination recommendations and administer HPV vaccination as early as possible in HPV-naive individuals. Because not all HR-HPV types are covered by the available HPV vaccines, other types may still cause CIN 3/high-grade squamous intraepithelial lesion. This requires further screening after vaccination, especially in women who were previously vaccinated with the bivalent or the quadrivalent HPV vaccine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Domroese, Christian Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilch, Henryk UNSPECIFIED UNSPECIFIED UNSPECIFIED Einzmann, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoemig-Markiefka, Birgid UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Michael Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-662788
DOI:	10.1097/LGT.0000000000000653
Journal or Publication Title:	J. Low. Genit. Tract. Dis.
Volume:	26
Number:	2
Page Range:	S. 122 - 127
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1526-0976
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUADRIVALENT VACCINE; DOUBLE-BLIND; HPV VACCINE; INFECTION; EFFICACY; BIVALENT; BURDEN; SYSTEM Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66278