Universität zu Köln

Dittrich-Salamon, Mara, Meyer, Anja ORCID: 0000-0001-9904-5070, Yan, Shuaifeng, Steinbach-Knoedgen, Eva, Kotschenreuther, Konstantin ORCID: 0000-0001-9455-2444, Stahl, David, Pesch, Carola Tho, Schiller, Joanna, Byrtus, Franziska, Jochimsen, Dorothee, Golumba-Nagy, Viktoria and Kofler, David M. (2022). Regulatory T Cells from Patients with Rheumatoid Arthritis Are Characterized by Reduced Expression of Ikaros Zinc Finger Transcription Factors. Cells, 11 (14). BASEL: MDPI. ISSN 2073-4409

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Abstract

Regulatory T (Treg) cells play an important role in immune tolerance and contribute to the prevention of autoimmune diseases, including rheumatoid arthritis (RA). The differentiation, function and stability of Treg cells is controlled by members of the Ikaros zinc finger transcription factor family. In this study, we aimed to reveal how the expression of Ikaros transcription factors is affected by disease activity in RA. Therefore, we analyzed the ex vivo expression of Ikaros, Helios, Aiolos and Eos in Treg cells, Th17 cells and Th1 cells from RA patients by flow cytometry. We found significantly reduced expression of Helios, Aiolos and Eos in Treg cells from RA patients as compared to healthy controls. Moreover, Helios and Aiolos levels correlated with disease activity, as assessed by DAS28-CRP. In addition, Ikaros, Helios and Aiolos were significantly downregulated in Th1 cells from RA patients, while no difference between healthy individuals and RA was observed in Th17 cells. In summary, Helios and Aiolos expression in Treg cells correlates with disease activity and the expression levels of Ikaros transcription factors are diminished in Treg cells from RA patients. This observation could explain the reduced stability of Treg cells in RA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dittrich-Salamon, Mara UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Anja UNSPECIFIED orcid.org/0000-0001-9904-5070 UNSPECIFIED Yan, Shuaifeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinbach-Knoedgen, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Kotschenreuther, Konstantin UNSPECIFIED orcid.org/0000-0001-9455-2444 UNSPECIFIED Stahl, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Pesch, Carola Tho UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiller, Joanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Byrtus, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Jochimsen, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Golumba-Nagy, Viktoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Kofler, David M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-663312
DOI:	10.3390/cells11142171
Journal or Publication Title:	Cells
Volume:	11
Number:	14
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FAMILY-MEMBERS; AIOLOS; HELIOS; TREGS; RATIO; EOS Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66331