Universität zu Köln

Grabowska, Martyna, Toth, Tibor I., Bueschges, Ansgar and Daun, Silvia ORCID: 0000-0001-7342-1015 (2022). Existence of a Long-Range Caudo-Rostral Sensory Influence in Terrestrial Locomotion. J. Neurosci., 42 (24). S. 4841 - 4852. WASHINGTON: SOC NEUROSCIENCE. ISSN 1529-2401

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Abstract

In multisegmented locomotion, coordination of all appendages is crucial for the generation of a proper motor output. In running for example, leg coordination is mainly based on the central interaction of rhythm generating networks, called central pattern generators (CPGs). In slower forms of locomotion, however, sensory feedback, which originates from sensory organs that detect changes in position, velocity and load of the legs??? segments, has been shown to play a more crucial role. How exactly sensory feedback influences the activity of the CPGs to establish functional neuronal connectivity is not yet fully understood. Using the female stick insect Carausius morosus, we show for the first time that a long-range caudo-rostral sensory connection exists and highlight that load as sensory signal is sufficient to entrain rhythmic motoneuron (MN) activity in the most rostral segment. So far, mainly rostro-caudal influencing pathways have been investigated where the strength of activation, expressed by the MN activity in the thoracic ganglia, decreases with the distance from the stepping leg to these ganglia. Here, we activated CPGs, producing rhythmic neuronal activity in the thoracic ganglia by using the muscarinic agonist pilocarpine and enforced the stepping of a single, remaining leg. This enabled us to study sensory influences on the CPGs??? oscillatory activity. Using this approach, we show that, in contrast to the distance-dependent activation of the protractor-retractor CPGs in different thoracic ganglia, there is no such dependence for the entrainment of the rhythmic activity of active protractor-retractor CPG networks by individual stepping legs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grabowska, Martyna UNSPECIFIED UNSPECIFIED UNSPECIFIED Toth, Tibor I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED Daun, Silvia UNSPECIFIED orcid.org/0000-0001-7342-1015 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-668691
DOI:	10.1523/JNEUROSCI.2290-20.2022
Journal or Publication Title:	J. Neurosci.
Volume:	42
Number:	24
Page Range:	S. 4841 - 4852
Date:	2022
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	1529-2401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATTERN GENERATING NETWORKS; STICK INSECT; INTERSEGMENTAL COORDINATION; WALKING MOVEMENTS; THORACIC GANGLIA; MOTOR-ACTIVITY; LEG; SYSTEM; INTERNEURONS; COCKROACHES Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66869