Universität zu Köln

Gamerith, Gabriele, Kloppenburg, Marcel, Mildner, Finn, Amann, Arno, Merkelbach-Bruse, Sabine, Heydt, Carina, Siemanowski, Janna, Buettner, Reinhard, Fiegl, Michael, Manzl, Claudia and Pall, Georg (2022). Molecular Characteristics of Radon Associated Lung Cancer Highlights MET Alterations. Cancers, 14 (20). BASEL: MDPI. ISSN 2072-6694

Full text not available from this repository.

Abstract

Simple Summary Lung cancer (LC) is the leading cause of cancer death worldwide. After smoking, one of the most prominent risk factors for LC development is radon (Rn) exposure. In our study we analysed and compared the genetic landscape of LC patients from a Rn exposed village with local matched non-exposed patients. Within the concordant genetic landscape, an increase in genetic MET proto-oncogene, receptor tyrosine kinase (MET) alteration in the Rn-exposed cohort was monitored, underlining the importance of routine MET testing and potential to enable a more effective treatment for this specific subgroup. Effective targeted treatment strategies resulted from molecular profiling of lung cancer with distinct prevalent mutation profiles in smokers and non-smokers. Although Rn is the second most important risk factor, data for Rn-dependent driver events are limited. Therefore, a Rn-exposed cohort of lung cancer patients was screened for oncogenic drivers and their survival and genetic profiles were compared with data of the average regional population. Genetic alterations were analysed in 20 Rn-exposed and 22 histologically matched non-Rn exposed LC patients using targeted Next generation sequencing (NGS) and Fluorescence In Situ Hybridization (FISH). Sufficient material and sample quality could be obtained in 14/27 non-exposed versus 17/22 Rn-exposed LC samples. Survival was analysed in comparison to a histologically and stage-matched regional non-exposed lung cancer cohort (n = 51) for hypothesis generating. Median overall survivals were 83.02 months in the Rn-exposed and 38.7 months in the non-exposed lung cancer cohort (p = 0.22). Genetic alterations of both patient cohorts were in high concordance, except for an increase in MET alterations and a decrease in TP53 mutations in the Rn-exposed patients in this small hypothesis generating study.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gamerith, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloppenburg, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mildner, Finn UNSPECIFIED UNSPECIFIED UNSPECIFIED Amann, Arno UNSPECIFIED UNSPECIFIED UNSPECIFIED Merkelbach-Bruse, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Heydt, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Siemanowski, Janna UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiegl, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Manzl, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Pall, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670739
DOI:	10.3390/cancers14205113
Journal or Publication Title:	Cancers
Volume:	14
Number:	20
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESIDENTIAL RADON; P53 GENE; MUTATIONS; EXPOSURE; EGFR; RAS; SMOKING; HOTSPOT; GALICIA; TP53 Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67073