Universität zu Köln

Hillebrandt, Sabina ORCID: 0000-0002-2628-385X, Keum, Changmin ORCID: 0000-0003-4952-2566, Deng, Yali, Chavas, Joel ORCID: 0000-0002-3559-5919, Galle, Charlie, Hardin, Thomas, Galluppi, Francesco and Gather, Malte C. . High Brightness, Highly Directional Organic Light-Emitting Diodes as Light Sources for Future Light-Amplifying Prosthetics in the Optogenetic Management of Vision Loss. Adv. Opt. Mater.. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 2195-1071

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Abstract

Optogenetic control of retinal cells transduced with light-sensitive channelrhodopsins can enable restoration of visual perception in patients with vision loss. However, a light intensity orders of magnitude higher than ambient light conditions is required to achieve robust cell activation. Relatively bulky wearable light amplifiers are currently used to deliver sufficient photon flux (>10(16) photons/cm(2)/s in a +/- 10 degrees emission cone) at a suitable wavelength (e.g., 600 nm for channelrhodopsin ChrimsonR). Here, ultrahigh brightness organic light-emitting diodes (OLEDs) with highly directional emission are developed, with the ultimate aim of providing high-resolution optogenetic control of thousands of retinal cells in parallel from a compact device. The orange-emitting phosphorescent OLEDs use doped charge transport layers, generate narrowband emission peaking at 600 nm, and achieve a luminance of 684 000 cd m(-2) at 15 V forward bias. In addition, tandem-stack OLEDs with a luminance of 1 152 000 cd m(-2) and doubled quantum efficiency are demonstrated, which greatly reduces electrical and thermal stress in these devices. At the photon flux required to trigger robust neuron firing in genetically modified retinal cells and when using heat sinking and realistic duty cycles (20% at 12.5 Hz), the tandem-stack OLEDs therefore show a greatly improved half-brightness lifetime of 800 h.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hillebrandt, Sabina UNSPECIFIED orcid.org/0000-0002-2628-385X UNSPECIFIED Keum, Changmin UNSPECIFIED orcid.org/0000-0003-4952-2566 UNSPECIFIED Deng, Yali UNSPECIFIED UNSPECIFIED UNSPECIFIED Chavas, Joel UNSPECIFIED orcid.org/0000-0002-3559-5919 UNSPECIFIED Galle, Charlie UNSPECIFIED UNSPECIFIED UNSPECIFIED Hardin, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Galluppi, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Gather, Malte C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671154
DOI:	10.1002/adom.202200877
Journal or Publication Title:	Adv. Opt. Mater.
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	2195-1071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EFFICIENCY ROLL-OFF; DEGRADATION MECHANISMS; DEVICES; ULTRATHIN; THERAPY; CIRCUIT; SAFETY; DRIVE Multiple languages Materials Science, Multidisciplinary; Optics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67115