Universität zu Köln

Hammerschmidt, Philipp and Bruening, Jens C. (2022). Contribution of specific ceramides to obesity-associated metabolic diseases. Cell. Mol. Life Sci., 79 (8). BASEL: SPRINGER BASEL AG. ISSN 1420-9071

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Abstract

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play specialized regulatory roles in cellular metabolism depending on their characteristic fatty acyl chain lengths and subcellular distribution. As obesity progresses, certain ceramide molecular species accumulate in metabolic tissues and cause cell-type-specific lipotoxic reactions that disrupt metabolic homeostasis and lead to the development of cardiometabolic diseases. Several mechanisms for ceramide action have been inferred from studies in vitro, but only recently have we begun to better understand the acyl chain length specificity of ceramide-mediated signaling in the context of physiology and disease in vivo. New discoveries show that specific ceramides affect various metabolic pathways and that global or tissue-specific reduction in selected ceramide pools in obese rodents is sufficient to improve metabolic health. Here, we review the tissue-specific regulation and functions of ceramides in obesity, thus highlighting the emerging concept of selectively inhibiting production or action of ceramides with specific acyl chain lengths as novel therapeutic strategies to ameliorate obesity-associated diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hammerschmidt, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671266
DOI:	10.1007/s00018-022-04401-3
Journal or Publication Title:	Cell. Mol. Life Sci.
Volume:	79
Number:	8
Date:	2022
Publisher:	SPRINGER BASEL AG
Place of Publication:	BASEL
ISSN:	1420-9071
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDUCED INSULIN-RESISTANCE; HIGH-FAT DIET; NOVO SPHINGOLIPID BIOSYNTHESIS; BETA-CELL FUNCTION; ENDOTHELIUM-DEPENDENT VASODILATION; MEMBRANE BIOPHYSICAL PROPERTIES; ENDOPLASMIC-RETICULUM STRESS; ACYL-CHAIN LENGTH; KILLER T-CELLS; SKELETAL-MUSCLE Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67126