Universität zu Köln

Llamas, Ernesto and Pulido, Pablo ORCID: 0000-0001-9092-3674 (2022). A proteostasis network safeguards the chloroplast proteome. Essays Biochem., 66 (2). S. 219 - 229. LONDON: PORTLAND PRESS LTD. ISSN 1744-1358

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Abstract

Several protein homeostasis (proteostasis) pathways safeguard the integrity of thousands of proteins that localize in plant chloroplasts, the indispensable organelles that perform photosynthesis, produce metabolites, and sense environmental stimuli. In this review, we discuss the latest efforts directed to define the molecular process by which proteins are imported and sorted into the chloroplast. Moreover, we describe the recently elucidated protein folding and degradation pathways that modulate the levels and activities of chloroplast proteins. We also discuss the links between the accumulation of misfolded proteins and the activation of signalling pathways that cope with folding stress within the organelle. Finally, we propose new research directions that would help to elucidate novel molecular mechanisms to maintain chloroplast proteostasis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Llamas, Ernesto UNSPECIFIED UNSPECIFIED UNSPECIFIED Pulido, Pablo UNSPECIFIED orcid.org/0000-0001-9092-3674 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671331
DOI:	10.1042/EBC20210058
Journal or Publication Title:	Essays Biochem.
Volume:	66
Number:	2
Page Range:	S. 219 - 229
Date:	2022
Publisher:	PORTLAND PRESS LTD
Place of Publication:	LONDON
ISSN:	1744-1358
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UBIQUITIN-PROTEASOME SYSTEM; HEAT-SHOCK RESPONSE; QUALITY CONTROL; CLP PROTEASE; PLANT DEVELOPMENT; ARABIDOPSIS; PROTEINS; ACCUMULATION; IMPORT; TRANSLOCATION Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67133