Universität zu Köln

Schmidt, Claudia C. ORCID: 0000-0002-1296-577X, Achilles, Elisabeth I. S., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2022). Distinct cognitive components and their neural substrates underlying praxis and language deficits following left hemisphere stroke. Cortex, 146. S. 200 - 216. PARIS: ELSEVIER MASSON, CORP OFF. ISSN 1973-8102

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Abstract

Apraxia is characterised by multiple deficits of higher motor functions, primarily caused by left hemisphere (LH) lesions to parietal-frontal praxis networks. While previous neuro-psychological and lesion studies tried to relate the various apraxic deficits to specific lesion sites, a comprehensive analysis of the different apraxia profiles and the related (impaired) motor-cognitive processes as well as their differential neural substrates in LH stroke is lacking. To reveal the cognitive mechanisms that underlie the different patterns of praxis and (related) language deficits, we applied principal component analysis (PCA) to the scores of sub-acute LH stroke patients (n = 91) in several tests of apraxia and aphasia. Voxel-based lesion-symptom mapping (VLSM) analyses were then used to investigate the neural substrates of the identified components. The PCA yielded a first component related to language functions and three components related to praxis functions, with each component associated with specific lesion patterns. Regarding praxis functions, performance in imitating arm/hand gestures was accounted for by a second component related to the left precentral gyrus and the inferior parietal lobule. Imitating finger configurations, pantomiming the use of objects related to the face, and actually using objects loaded on component 3, related to the left anterior intraparietal sulcus and angular gyrus. The last component represented the imitation of bucco-facial gestures and was linked to the basal ganglia and LH white matter tracts. The results further revealed that pantomime of (limb-related) object use depended on both the component 2 and 3, which were shared with gesture imitation and actual object use. Data support and extend the notion that apraxia represents a multi-componential syndrome comprising different (impaired) motor-cognitive processes, which dissociate - at least partially - from language processes. The distinct components might be disturbed to a varying degree following LH stroke since they are associated with specific lesion patterns within the LH. (C) 2021 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Claudia C. UNSPECIFIED orcid.org/0000-0002-1296-577X UNSPECIFIED Achilles, Elisabeth I. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671440
DOI:	10.1016/j.cortex.2021.11.004
Journal or Publication Title:	Cortex
Volume:	146
Page Range:	S. 200 - 216
Date:	2022
Publisher:	ELSEVIER MASSON, CORP OFF
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOOL-USE; BASAL GANGLIA; BRAIN-REGIONS; APRAXIA; LESION; IMITATION; PANTOMIME; APHASIA; REPRESENTATIONS; GESTURES Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67144