Universität zu Köln

Silling, Steffi, Kreuter, Alexander and Wieland, Ulrike (2022). Human polyomavirus-associated skin diseases. Hautarzt, 73 (6). S. 426 - 434. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1173

Full text not available from this repository.

Abstract

Of the 15 currently known human polyomaviruses (HPyV), eight have been found on healthy skin. Merkel cell polyomavirus (MCPyV), HPyV6, HPyV7, and to a lesser extent Saint Louis polyomavirus (STLPyV) are considered part of the human cutaneous virome. The most important cutaneous polyomavirus, MCPyV, causes the majority of Merkel cell carcinomas (MCC). MCC is a rare but very aggressive malignant skin tumor that affects both immunocompetent and immunosuppressed patients. A steady increase in incidence rates of this skin tumor has been observed in recent decades. MCC occurs primarily on sunlight-exposed skin of fair-skinned individuals. Risk factors for MCC development include immunosuppression and advanced age. In immunocompromised individuals, primary infection with trichodysplasia spinulosa-associated polyomavirus (TSPyV) can cause the very rare skin disease trichodysplasia spinulosa (TS). Keratin spines (spicules), mainly in the center of the face, clinically characterize this disease. Skin lesions associated with further HPyV have been described exclusively in immunocompromised individuals. For HPyV6 and HPyV7, cases of epithelial proliferation and pruritic dyskeratotic dermatitis have been published. HPyV9 and New Jersey polyomavirus (NJPyV-13) were each found in different skin lesions of individual patients. The role of these polyomaviruses in the development of the skin lesions is still unclear.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Silling, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, Ulrike UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673605
DOI:	10.1007/s00105-022-04993-8
Journal or Publication Title:	Hautarzt
Volume:	73
Number:	6
Page Range:	S. 426 - 434
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1173
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MERKEL CELL-CARCINOMA; SPINULOSA-ASSOCIATED POLYOMAVIRUS; TRICHODYSPLASIA-SPINULOSA; T-ANTIGEN; ANGIOLYMPHOID HYPERPLASIA; TRANSPLANT RECIPIENT; NO EVIDENCE; INFECTION; IDENTIFICATION; PREVALENCE Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67360