Universität zu Köln

Pesta, Dominik ORCID: 0000-0002-5089-3586 and Jordan, Jens ORCID: 0000-0003-4518-0706 (2022). INDY as a Therapeutic Target for Cardio-Metabolic Disease. Metabolites, 12 (3). BASEL: MDPI. ISSN 2218-1989

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Abstract

Decreased expression of the plasma membrane citrate transporter INDY (acronym I'm Not Dead, Yet) promotes longevity and protects from high-fat diet- and aging-induced metabolic derangements. Preventing citrate import into hepatocytes by different strategies can reduce hepatic triglyceride accumulation and improve hepatic insulin sensitivity, even in the absence of effects on body composition. These beneficial effects likely derive from decreased hepatic de novo fatty acid biosynthesis as a result of reduced cytoplasmic citrate levels. While in vivo and in vitro studies show that inhibition of INDY prevents intracellular lipid accumulation, body weight is not affected by organ-specific INDY inhibition. Besides these beneficial metabolic effects, INDY inhibition may also improve blood pressure control through sympathetic nervous system inhibition, partly via reduced peripheral catecholamine synthesis. These effects make INDY a promising candidate with bidirectional benefits for improving both metabolic disease and blood pressure control.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pesta, Dominik UNSPECIFIED orcid.org/0000-0002-5089-3586 UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673880
DOI:	10.3390/metabo12030244
Journal or Publication Title:	Metabolites
Volume:	12
Number:	3
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-1989
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FATTY LIVER-DISEASE; CARDIOVASCULAR OUTCOMES; INSULIN SENSITIVITY; NEPRILYSIN INHIBITION; HEPATIC STEATOSIS; DROSOPHILA INDY; ACID SYNTHESIS; HEART-RATE; LIFE-SPAN; RECEPTOR Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67388