Universität zu Köln

Echterdiek, Fabian ORCID: 0000-0001-7239-4959, Kitterer, Daniel, Dippon, Juergen, Ott, Matthias, Paul, Gregor, Latus, Joerg and Schwenger, Vedat (2022). Outcome of kidney transplantations from >= 65-year-old deceased donors with acute kidney injury. Clin. Transplant., 36 (5). HOBOKEN: WILEY. ISSN 1399-0012

Full text not available from this repository.

Abstract

Kidney transplantation (KT) from donors with acute kidney injury (AKI) has been associated with delayed graft function (DGF) but similar graft survival compared with KT from donors without AKI. Kidneys from >= 65-year-old donors with comorbidities are more susceptible to cold ischemia time (CIT) and DGF and it is unknown whether such elderly kidneys with AKI can also be transplanted with satisfactory outcomes. All KTs from >= 65-year-old donors performed at our center from 1999 to 2019 (n = 233) were retrospectively analyzed and short- as well as long-term outcomes were compared for KTs from donors with (n = 64) and without AKI (n = 169). There were no significant differences regarding the frequency of DGF as well as the estimated glomerular filtration rate (eGFR) 1 and 3 years post-transplant between the no-AKI and the AKI group (DGF: no-AKI 30.2% vs. AKI 40.6%, P = .17; eGFR at 1-year: 31.9 ml/min/1.73 m(2) vs. 35.5 ml/min/1.73 m(2), P = .32; at 3-years: 33.8 ml/min/1.73 m(2) vs. 40.9 ml/min/1.73 m(2), P = .18; respectively). Death-censored graft survival and patient survival were also not significantly different. Multivariable Cox regression analysis did not identify AKI as a significant risk factor for graft loss or death. Following careful donor and recipient selection, kidneys from >= 65-year-old AKI donors may potentially be transplanted with satisfactory outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Echterdiek, Fabian UNSPECIFIED orcid.org/0000-0001-7239-4959 UNSPECIFIED Kitterer, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Dippon, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Latus, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwenger, Vedat UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674056
DOI:	10.1111/ctr.14612
Journal or Publication Title:	Clin. Transplant.
Volume:	36
Number:	5
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-0012
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SINGLE-CENTER EXPERIENCE; SURVIVAL; RECIPIENTS; SCORE; TIME Multiple languages Surgery; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67405