Universität zu Köln

Pelzer, Esther Annegret, Stuermer, Sophie, Feis, Delia-Lisa, Melzer, Corina, Schwartz, Frank, Scharge, Marcel, Eggers, Carsten, Tittgemeyer, Marc and Timmermann, Lars ORCID: 0000-0002-5301-3580 (2022). Clustering of Parkinson subtypes reveals strong influence of DRD2 polymorphism and gender. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Most classification approaches for idiopathic Parkinson's disease subtypes primarily focus on motor and non-motor symptoms. Besides these characteristics, other features, including gender or genetic polymorphism of dopamine receptors are potential factors influencing the disease's phenotype. By utilizing a kmeans-clustering algorithm we were able to identify three subgroups mainly characterized by gender, DRD2 Taq1A (rs1800497) polymorphism-associated with changes in dopamine signaling in the brain-and disease progression. A subsequent regression analysis of these subgroups further suggests an influence of their characteristics on the daily levodopa dosage, an indicator for medication response. These findings could promote further enhancements in individualized therapies for idiopathic Parkinson's disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pelzer, Esther Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuermer, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Feis, Delia-Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Melzer, Corina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwartz, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Scharge, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED orcid.org/0000-0002-5301-3580 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674200
DOI:	10.1038/s41598-022-09657-0
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOPAMINE D2; NONMOTOR SYMPTOMS; DISEASE; HETEROGENEITY; ASSOCIATION; ONSET; MOTOR; RISK Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67420