Universität zu Köln

Gietzelt, Caroline ORCID: 0000-0002-9145-7385, Luke, Jan-Niklas, Adler, Werner, Dietlein, Thomas S., Lappas, Alexandra, Prokosch-Willing, Verena, Roters, Sigrid, Heindl, Ludwig M., Cursiefen, Claus and Enders, Philip (2022). Short-term changes in Bruch's membrane opening-based morphometrics during the first week after trabeculectomy. Graefes Arch. Clin. Exp. Ophthalmol., 260 (10). S. 3321 - 3330. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Purpose To evaluate the dynamics of Brach's membrane opening-based morphometrics of the optic nerve head (ONH) using spectral-domain optical coherence tomography (SD-OCT) during the first week after glaucoma surgery by trabeculectomy with mitomycin C. Methods Prospective, longitudinal analysis of 25 eyes of 25 patients treated by trabeculectomy. Twenty-four eyes had evaluable postoperative SD-OCT examinations. Bruch's membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness were analyzed at baseline before surgery, 1 day, 2 to 3 days, and 1 week after surgery. Changes compared to baseline were correlated to intraocular pressure (TOP). Results One day after surgery, the mean BMO-MRW changed by+ 26.17 mu m, p= 0.001 (mean IOP reduction by 17.01 mmHg) This increase persisted on day 2-3 with a mean increase of BMO-MRW of+25.33 mu m, p =0.001 (mean IOP reduction by 20 46 mmHg) and by week 1 with a mean BMO-MRW increase of+ 33.17 mu m, p < 0.001 (mean IOP reduction by 22.55 mmHg) The increase in BMO-MRW correlated significantly with the reduction of TOP on day 1 (Spearman's rho rho= 0.656, p= 0.003) and d2-3 (Spearman's rho rho= 0.479, p= 0.038). There was no statistically significant correlation found between the IOP and the increase in BMO-MRW in week 1. RNFL thickness showed no significant changes at day 1 as well as days 2-3 (p >= 0.078, respectively). It showed a small but significant increase in week 1 by 3.94 mu m, p = 0.015. Conclusions Structural reversal of disc cupping in BMO-MRW occurs as early as 1 day after trabeculectomy and correlates to the extent of the IOP reduction. During the whole first week after surgery, a strong increase in BMO-MRW can be noted. The changes in BMO-based parameters need to be considered when evaluating patients' longitudinal follow-up.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gietzelt, Caroline UNSPECIFIED orcid.org/0000-0002-9145-7385 UNSPECIFIED Luke, Jan-Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, Werner UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lappas, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch-Willing, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Roters, Sigrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674568
DOI:	10.1007/s00417-022-05644-3
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	260
Number:	10
Page Range:	S. 3321 - 3330
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPTICAL COHERENCE TOMOGRAPHY; FIBER LAYER THICKNESS; MINIMUM RIM WIDTH; INTRAOCULAR-PRESSURE; NERVE HEAD; GLAUCOMA; PROGRESSION; DISPLACEMENT Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67456