Acharya, Aviseka, Nemade, Harshal ORCID: 0000-0002-2704-181X, Papadopoulos, Symeon, Hescheler, Jurgen, Neumaier, Felix, Schneider, Toni, Prasad, Krishna Rajendra, Khan, Khadija, Hemmersbach, Ruth, Gusmao, Eduardo Gade, Mizi, Athanasia, Papantonis, Argyris and Sachinidis, Agapios (2022). Microgravity-induced stress mechanisms in human stem cell-derived cardiomyocytes. iScience, 25 (7). CAMBRIDGE: CELL PRESS. ISSN 2589-0042

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Abstract

Exposure to outer space microgravity poses a risk for the development of various pathologies including cardiovascular disease. To study this, we derived cardiomyocytes (CMs) from human-induced pluripotent stem cells and exposed them to simulated microgravity (SMG). We combined different omits and chromosome conformation capture technologies with live-cell imaging of various transgenic lines to discover that SMG impacts on the contractile velocity and function of CMs via the induction of senescence processes. This is linked to SMG induced changes of reactive oxygen species (ROS) generation and energy metabolism by mitochondria. Taken together, we uncover a microgravity-controlled axis causing contractile dysfunctions to CMs. Our findings can contribute to the design of preventive and therapeutic strategies against senescence-associated disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Acharya, AvisekaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemade, HarshalUNSPECIFIEDorcid.org/0000-0002-2704-181XUNSPECIFIED
Papadopoulos, SymeonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hescheler, JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumaier, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, ToniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, Krishna RajendraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khan, KhadijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hemmersbach, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gusmao, Eduardo GadeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mizi, AthanasiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papantonis, ArgyrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachinidis, AgapiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-674919
DOI: 10.1016/j.isci.2022.104577
Journal or Publication Title: iScience
Volume: 25
Number: 7
Date: 2022
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 2589-0042
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PURIFICATION; HYPERTROPHY; DYSFUNCTION; MITOTIMER; SYSTEM; HEART; TOOLMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67491

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