Universität zu Köln

Stoll, Sandra Emily, Paul, Eldho, Pilcher, David, Udy, Andrew and Burrell, Aidan (2022). Hyperoxia and mortality in conventional versus extracorporeal cardiopulmonary resuscitation. J. Crit. Care, 69. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1557-8615

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Abstract

Purpose: Hyperoxia has been associated with adverse outcomes in post cardiac arrest (CA) patients. Study-objective was to examine the association between hyperoxia and 30-day mortality in a mixed cohort of two different modes of Cardiopulmonary Resuscitation (CPR): Extracorporeal (ECPR) vs. Conventional (CCPR). Material and methods: In this retrospective cohort study of CA patients admitted to a tertiary level CA centre in Australia (over a 6.5-year time period) mean arterial oxygen levels (PaO2) and episodes of extreme hyperoxia (maximum of mean PaO2 >= 300 mmHg) were analysed over the first 8 days post CA. Results: One hundred and sixty-nine post CA patients were assessed (ECPR n = 79 / CCPR n = 90). Mean PaO2- levels were higher in the ECPR vs CCPR group (211 mmHg +/- 58.4 vs 119 mmHg +/- 18.1; p < 0.0001) as was the proportion with at least one episode of extreme hyperoxia (74.7% vs 16.7%; p < 0.001). After adjusting for confounders and the mode of CPR any episode of extreme hyperoxia was independently associated with a 2.52-fold increased risk of 30-day mortality (OR: 2.52, 95% CI: 1.06-5.98; p = 0.036). Conclusions: We found extreme hyperoxia was more common in ECPR patients in the first 8 days post CA and independently associated with higher 30-day mortality, irrespective of the CPR-mode. (C) 2022 Published by Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stoll, Sandra Emily UNSPECIFIED UNSPECIFIED UNSPECIFIED Paul, Eldho UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilcher, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Udy, Andrew UNSPECIFIED UNSPECIFIED UNSPECIFIED Burrell, Aidan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675278
DOI:	10.1016/j.jcrc.2022.154001
Journal or Publication Title:	J. Crit. Care
Volume:	69
Date:	2022
Publisher:	W B SAUNDERS CO-ELSEVIER INC
Place of Publication:	PHILADELPHIA
ISSN:	1557-8615
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC-ARREST; ARTERIAL HYPEROXIA; PARTIAL-PRESSURE; OXYGEN-THERAPY; LIFE-SUPPORT; ASSOCIATION; OUTCOMES; REPERFUSION; CONSENSUS; ECMO Multiple languages Critical Care Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67527