Universität zu Köln

Jensen, Vivi F. H., Molck, Anne-Marie, Nowak, Jette, Wohlfarth, Maria, Nuesken, Eva, Demozay, Damien, Nuesken, Kai-Dietrich and Bogh, Ingrid B. (2022). Placental nutrient transporters adapt during persistent maternal hypoglycaemia in rats. PLoS One, 17 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Maternal malnutrition is associated with decreased nutrient transfer to the foetus, which may lead to foetal growth restriction, predisposing children to a variety of diseases. However, regulation of placental nutrient transfer during decreased nutrient availability is not fully understood. In the present study, the aim was to investigate changes in levels of placental nutrient transporters accompanying maternal hypoglycaemia following different durations and stages of gestation in rats. Maternal hypoglycaemia was induced by insulin-infusion throughout gestation until gestation day (GD)20 or until end of organogenesis (GD17), with sacrifice on GD17 or GD20. Protein levels of placental glucose transporters GLUT1 (45/55 kDa isotypes) and GLUT3, amino acid transporters SNAT1 and SNAT2, and insulin receptor (InsR) were assessed. On GD17, GLUT1-45, GLUT3, and SNAT1 levels were increased and InsR levels decreased versus controls. On GD20, following hypoglycaemia throughout gestation, GLUT3 levels were increased, GLUT1-55 showed the same trend. After cessation of hypoglycaemia at end of organogenesis, GLUT1-55, GLUT3, and InsR levels were increased versus controls, whereas SNAT1 levels were decreased. The increases in levels of placental nutrient transporters seen during maternal hypoglycaemia and hyperinsulinemia likely reflect an adaptive response to optimise foetal nutrient supply and development during limited availability of glucose.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jensen, Vivi F. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Molck, Anne-Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Nowak, Jette UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlfarth, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Demozay, Damien UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Kai-Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogh, Ingrid B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675403
DOI:	10.1371/journal.pone.0265988
Journal or Publication Title:	PLoS One
Volume:	17
Number:	3
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AMINO-ACID-TRANSPORT; FETAL-GROWTH; INSULIN-RECEPTORS; GLUCOSE-TRANSPORT; DOWN-REGULATION; EXPRESSION; TROPHOBLAST; PREGNANCY; RESTRICTION; METABOLISM Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67540