Universität zu Köln

Nierer, Lukas, Kamp, Florian, Reiner, Michael, Corradini, Stefanie ORCID: 0000-0001-8709-7252, Rabe, Moritz ORCID: 0000-0002-7085-4066, Dietrich, Olaf ORCID: 0000-0001-6182-5039, Parodi, Katia, Belka, Claus, Kurz, Christopher and Landry, Guillaume ORCID: 0000-0003-1707-4068 (2022). Evaluation of an anthropomorphic ion chamber and 3D gel dosimetry head phantom at a 0.35 T MR-linac using separate 1.5 T MR-scanners for gel readout. Z. Med. Phys., 32 (3). S. 312 - 326. AMSTERDAM: ELSEVIER. ISSN 1876-4436

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Abstract

Purpose: To date, no universally accepted technique for the evaluation of the overall dosimetric performance of hybrid integrated magnetic resonance imaging (MR) - linear accelerators (linacs) is available. We report on the suitability and reliability of a novel phantom with modular inserts for combined polymer gel (PG) and ionisation chamber (IC) measurements at a 0.35 T MR-linac. Methods: Three 3D-printed, modular head phantoms, based on real patient anatomy, were used for repeated (2 times) PG irradiations of cranial treatment plans on a 0.35 T MR-linac. The PG readout was performed on two 1.5 T diagnostic MR-scanners to reduce scanning time. The PG dose volumes were normalised to the IC dose (normalised dose N1) and to the median planning target volume dose (normalised dose N2). Linearity of the PG dose response was validated and dose profiles, centres of mass (COM) of the 95% isodoses and dose volume histograms (DVH) were compared between planned and measured dose distributions and a 3D gamma analysis was performed.Results: Dose linearity of the PG was good (R2 > 0.99 for all linear fit functions). High agreement was found between planned and measured dose volumes in the dose profiles and DVHs. The largest dose deviation was found in the intermediate dose region (mean dose deviation 0.2 Gy; 5.6%). A mean COM offset of 1.2 mm indicated high spatial accuracy. Mean 3D gamma passing rates (2%, 2 mm) of 83.3% for N1 and 91.6% for N2 dose distributions were determined. When comparing repeated PG measurements to each other, a mean gamma passing rate of 95.7% was found.Conclusion: The new modular phantom was found practical for use at a 0.35 T MR-linac. In contrast to the high dose region, larger mean deviations were found in the mid dose range. The PG measurements showed high reproducibility. The MR-linac performed well in a non-adaptive setting in terms of spatial and dosimetric accuracy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nierer, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Reiner, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Corradini, Stefanie UNSPECIFIED orcid.org/0000-0001-8709-7252 UNSPECIFIED Rabe, Moritz UNSPECIFIED orcid.org/0000-0002-7085-4066 UNSPECIFIED Dietrich, Olaf UNSPECIFIED orcid.org/0000-0001-6182-5039 UNSPECIFIED Parodi, Katia UNSPECIFIED UNSPECIFIED UNSPECIFIED Belka, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurz, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Landry, Guillaume UNSPECIFIED orcid.org/0000-0003-1707-4068 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675812
DOI:	10.1016/j.zemedi.2022.01.006
Journal or Publication Title:	Z. Med. Phys.
Volume:	32
Number:	3
Page Range:	S. 312 - 326
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1876-4436
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ONLINE ADAPTIVE RADIOTHERAPY; POLYMER GEL; MAGNETIC-RESONANCE; RADIATION-THERAPY; ACCURACY; IMPLEMENTATION; DEPENDENCE; PRECISION Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67581