Universität zu Köln

Saha, Shekhar, Mladenova, Ralitsa, Radner, Caroline, Horke, Konstanze Maria, Buech, Joscha ORCID: 0000-0002-8749-2962, Schnackenburg, Philipp, Ali, Ahmad, Peterss, Sven ORCID: 0000-0003-1880-152X, Juchem, Gerd, Luehr, Maximilian ORCID: 0000-0002-0645-1764, Hagl, Christian and Joskowiak, Dominik (2022). Health-Related Quality of Life following Surgery for Native and Prosthetic Valve Infective Endocarditis. J. Clin. Med., 11 (13). BASEL: MDPI. ISSN 2077-0383

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Abstract

Objectives: The objective of this study was to compare the long-term outcomes and health-related quality of life (HRQOL) of patients following surgery for infective native valve endocarditis (NVE) and prosthetic valve endocarditis (PVE). Methods: We retrospectively identified 633 consecutive patients who had undergone surgery for infective endocarditis at our center between January 2005 and October 2018. The patients were interviewed, and the SF-36 survey was used to assess the HRQOL of survivors. Propensity score matching (2:1) was performed with data from a German reference population. Multivariable analysis incorporated binary logistic regression using a forward stepwise (conditional) model. Results: The median age of the cohort was 67 (55-74) years, and 75.6% were male. Operative mortality was 13.7% in the NVE group and 21.6% in the PVE group (p = 0.010). The overall survival at 1 year was 88.0% and was comparable between the groups. The physical health summary scores were 49 (40-55) for the NVE patients and 45 (37-52) for the PVE patients (p = 0.043). The median mental health summary scores were 52 (35-57) and 49 (41-56), respectively (p = 0.961). On comparison of the HRQOL to the reference population, the physical health summary scores were comparable. However, significant differences were observed with regard to the mental health summary scores (p = 0.005). Conclusions: Our study shows that there are significant differences in the various domains of HRQOL, not only between NVE and PVE patients, but also in comparison to healthy individuals. In addition to preoperative health status, it is important to consider the patient's expectations regarding surgery. Further prospective studies are required.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Saha, Shekhar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mladenova, Ralitsa UNSPECIFIED UNSPECIFIED UNSPECIFIED Radner, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Horke, Konstanze Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Buech, Joscha UNSPECIFIED orcid.org/0000-0002-8749-2962 UNSPECIFIED Schnackenburg, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Ali, Ahmad UNSPECIFIED UNSPECIFIED UNSPECIFIED Peterss, Sven UNSPECIFIED orcid.org/0000-0003-1880-152X UNSPECIFIED Juchem, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Luehr, Maximilian UNSPECIFIED orcid.org/0000-0002-0645-1764 UNSPECIFIED Hagl, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Joskowiak, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675869
DOI:	10.3390/jcm11133599
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	13
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC-SURGERY; SF-36 Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67586