Universität zu Köln

Gruell, Henning, Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Weber, Timm, Barnes, Christopher O., Kreer, Christoph and Klein, Florian ORCID: 0000-0003-1376-1792 (2022). Antibody-mediated neutralization of SARS-CoV-2. Immunity, 55 (6). S. 925 - 945. CAMBRIDGE: CELL PRESS. ISSN 1097-4180

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Abstract

Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gruell, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Vanshylla, Kanika UNSPECIFIED orcid.org/0000-0003-4552-9170 UNSPECIFIED Weber, Timm UNSPECIFIED UNSPECIFIED UNSPECIFIED Barnes, Christopher O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675877
DOI:	10.1016/j.immuni.2022.05.005
Journal or Publication Title:	Immunity
Volume:	55
Number:	6
Page Range:	S. 925 - 945
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4180
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA VACCINATION; RECEPTOR-BINDING DOMAIN; B-CELL MEMORY; HUMORAL IMMUNITY; SPIKE; COVID-19; INFECTION; POTENT; MATURATION; PROTECTION Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67587