Universität zu Köln

Prange, Stephane ORCID: 0000-0002-0812-7634, Theis, Hendrik, Banwinkler, Magdalena ORCID: 0000-0001-7086-9973 and van Eimeren, Thilo (2022). Molecular Imaging in Parkinsonian Disorders-What's New and Hot? Brain Sci., 12 (9). BASEL: MDPI. ISSN 2076-3425

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Abstract

Neurodegenerative parkinsonian disorders are characterized by a great diversity of clinical symptoms and underlying neuropathology, yet differential diagnosis during lifetime remains probabilistic. Molecular imaging is a powerful method to detect pathological changes in vivo on a cellular and molecular level with high specificity. Thereby, molecular imaging enables to investigate functional changes and pathological hallmarks in neurodegenerative disorders, thus allowing to better differentiate between different forms of degenerative parkinsonism, improve the accuracy of the clinical diagnosis and disentangle the pathophysiology of disease-related symptoms. The past decade led to significant progress in the field of molecular imaging, including the development of multiple new and promising radioactive tracers for single photon emission computed tomography (SPECT) and positron emission tomography (PET) as well as novel analytical methods. Here, we review the most recent advances in molecular imaging for the diagnosis, prognosis, and mechanistic understanding of parkinsonian disorders. First, advances in imaging of neurotransmission abnormalities, metabolism, synaptic density, inflammation, and pathological protein aggregation are reviewed, highlighting our renewed understanding regarding the multiplicity of neurodegenerative processes involved in parkinsonian disorders. Consequently, we review the role of molecular imaging in the context of disease-modifying interventions to follow neurodegeneration, ensure stratification, and target engagement in clinical trials.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Prange, Stephane UNSPECIFIED orcid.org/0000-0002-0812-7634 UNSPECIFIED Theis, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Banwinkler, Magdalena UNSPECIFIED orcid.org/0000-0001-7086-9973 UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676414
DOI:	10.3390/brainsci12091146
Journal or Publication Title:	Brain Sci.
Volume:	12
Number:	9
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHOLINERGIC SYSTEM; DISEASE; PET; LRRK2; DEGENERATION; HYPOMETABOLISM; AVAILABILITY; DYSFUNCTION; PROGRESSION; IMPAIRMENT Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67641