Universität zu Köln

Gebehart, Corinna ORCID: 0000-0003-4426-6225, Hooper, Scott L. and Büschges, Ansgar ORCID: 0000-0003-2123-1900 (2022). Non-linear multimodal integration in a distributed premotor network controls proprioceptive reflex gain in the insect leg. Current Biology, 32 (17). 3847 - 3859. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

Producing context-appropriate motor acts requires integrating multiple sensory modalities. Presynaptic inhibition of proprioceptive afferent neurons(1-4) and afferents of different modalities targeting the same motor neurons (MNs)(5-7) underlies some of this integration. However, in most systems, an interneuronal network is interposed between sensory afferents and MNs. How these networks contribute to this integration, particularly at single-neuron resolution, is little understood. Context-specific integration of load and movement sensory inputs occurs in the stick insect locomotory system,(6,8-12) and both inputs feed into a network of premotor nonspiking interneurons (NSIs).(8) We analyzed how load altered movement signal processing in the stick insect femur-tibia (FTi) joint control system by tracing the interaction of FTi movement(13-15) (femoral chordotonal organ [fCO]) and load(13,15,16) (tibial campaniform sensilla [CS]) signals through the NSI network to the slow extensor tibiae (SETi) MN, the extensor MN primarily active in non-walking animals.(17-19) On the afferent level, load reduced movement signal gain by presynaptic inhibition. In the NSI network, graded responses to movement and load inputs summed nonlinearly, increasing the gain of NSIs opposing movement-induced reflexes and thus decreasing the SETi and extensor tibiae muscle movement reflex responses. Gain modulation was movement-parameter specific and required presynaptic inhibition. These data suggest that gain changes in distributed premotor networks, specifically the relative weighting of antagonistic pathways, could be a general mechanism by which multiple sensory modalities are integrated to generate context-appropriate motor activity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gebehart, Corinna UNSPECIFIED orcid.org/0000-0003-4426-6225 UNSPECIFIED Hooper, Scott L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Büschges, Ansgar UNSPECIFIED orcid.org/0000-0003-2123-1900 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676544
DOI:	10.1016/j.cub.2022.07.005
Journal or Publication Title:	Current Biology
Volume:	32
Number:	17
Page Range:	3847 - 3859
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Zoologisches Institut
Subjects:	Life sciences
Uncontrolled Keywords:	Keywords Language TIBIA CONTROL-SYSTEM; STICK INSECT; PRESYNAPTIC INHIBITION; NEURAL BASIS; SENSORIMOTOR PATHWAYS; CUNICULINA-IMPIGRA; MOTOR CONTROL; NONSPIKING INTERNEURONS; CAMPANIFORM SENSILLA; MUSCLE SYNERGIES Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/67654