Universität zu Köln

Siggel, Robert, Spital, Christel, Lentzsch, Anna and Liakopoulos, Sandra (2023). Optical coherence tomography angiography for the detection of macular neovascularization-comparison of en face versus cross-sectional view. Eye, 37 (2). S. 256 - 263. LONDON: SPRINGERNATURE. ISSN 1476-5454

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Abstract

Purpose To evaluate sensitivity and specificity of swept source-optical coherence tomography angiography (SS-OCTA) en face images versus cross-sectional OCTA versus a combination of both for the detection of macular neovascularization (MNV). Design Prospective cohort study. Participants Consecutive patients with various chorioretinal diseases and subretinal hyperreflective material (SHRM) and/or pigment epithelial detachment (PED) on OCT possibly corresponding to MNV in at least one eye. Methods 102 eyes of 63 patients with fluorescein angiography (FA), OCT and SS-OCTA performed on the same day were included. FA images, the outer retina to choriocapillaris (ORCC) OCTA en face slab, a manually modified en face slab ('custom slab'), cross-sectional OCTA and a combination of OCTA en face and cross-section were evaluated for presence of MNV. Main outcome measures Sensitivity and specificity for MNV detection, as well as the concordance was calculated using FA as the reference. Results OCTA en face imaging alone yielded a sensitivity of 46.3% (automated)/78.1% (custom) and specificity of 93.4% (automated)/88.5% (custom) for MNV detection. Cross-sectional OCTA (combination with en face) resulted in a sensitivity of 85.4% (82.9%) and specificity of 82.0% (85.3%). Concordance to FA was moderate for automated en face OCTA (kappa = 0.43), and substantial for custom en face OCTA (kappa = 0.67), cross-sectional OCTA (kappa = 0.66) and the combination (kappa = 0.68). Conclusion Segmentation errors result in decreased sensitivity for MNV detection on automatically generated OCTA en face images. Cross-sectional OCTA allows detection of MNV without manual modification of segmentation lines and should be used for evaluation of MNV on OCTA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Siggel, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Spital, Christel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lentzsch, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676635
DOI:	10.1038/s41433-021-01892-5
Journal or Publication Title:	Eye
Volume:	37
Number:	2
Page Range:	S. 256 - 263
Date:	2023
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHOROIDAL NEOVASCULARIZATION; OCT ANGIOGRAPHY; TYPE-1 NEOVASCULARIZATION; SPECTRAL-DOMAIN; DEGENERATION; RANIBIZUMAB Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67663