Universität zu Köln

Walter, Helene Luise, Pikhovych, Anton, Endepols, Heike, Rotthues, Steffen, Baermann, Johannes, Backes, Heiko, Hoehn, Mathias, Wiedermann, Dirk, Neumaier, Bernd, Fink, Gereon Rudolf, Rueger, Maria Adele ORCID: 0000-0001-8036-395X and Schroeter, Michael (2022). Transcranial-Direct-Current-Stimulation Accelerates Motor Recovery After Cortical Infarction in Mice: The Interplay of Structural Cellular Responses and Functional Recovery. Neurorehabil. Neural Repair, 36 (10-11). S. 701 - 715. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1552-6844

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Abstract

Background. Transcranial direct current stimulation (tDCS) promotes recovery after stroke in humans. The underlying mechanisms, however, remain to be elucidated. Animal models suggest tDCS effects on neuroinflammation, stem cell proliferation, neurogenesis, and neural plasticity. Objective. In a longitudinal study, we employed tDCS in the subacute and chronic phase after experimental focal cerebral ischemia in mice to explore the relationship between functional recovery and cellular processes. Methods. Mice received photothrombosis in the right motor cortex, verified by Magnetic Resonance Imaging. A composite neuroscore quantified subsequent functional deficits. Mice received tDCS daily: either 5 sessions from day 5 to 9, or 10 sessions with days 12 to 16 in addition. TDCS with anodal or cathodal polarity was compared to sham stimulation. Further imaging to assess proliferation and neuroinflammation was performed by immunohistochemistry at different time points and Positron Emission Tomography at the end of the observation time of 3 weeks. Results. Cathodal tDCS at 198 kC/m(2) (220A/m(2)) between days 5 and 9 accelerated functional recovery, increased neurogenesis, decreased microglial activation, and mitigated CD 16/32-expression associated with M1-phenotype. Anodal tDCS exerted similar effects on neurogenesis and microglial polarization but not on recovery of function or microglial activation. TDCS on days 12 to 16 after stroke did not induce any further effects, suggesting that the therapeutic time window was closed by then. Conclusion. Overall, data suggest that non-invasive neuromodulation by tDCS impacts neurogenesis and microglial activation as critical cellular processes influencing functional recovery during the early phase of regeneration from focal cerebral ischemia.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Walter, Helene Luise UNSPECIFIED UNSPECIFIED UNSPECIFIED Pikhovych, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Endepols, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Rotthues, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Baermann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Backes, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehn, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiedermann, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueger, Maria Adele UNSPECIFIED orcid.org/0000-0001-8036-395X UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676916
DOI:	10.1177/15459683221124116
Journal or Publication Title:	Neurorehabil. Neural Repair
Volume:	36
Number:	10-11
Page Range:	S. 701 - 715
Date:	2022
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	1552-6844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MOUSE-BRAIN; STROKE; CONNECTIVITY; POSTSTROKE; NEUROINFLAMMATION; DEPRESSION; INDUCTION; ISCHEMIA; SAFETY; MODEL Multiple languages Clinical Neurology; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67691