Universität zu Köln

Schafmeyer, Leonie, Al-Monajjed, Mike, Linden, Tobias, Wunram, Heidrun Lioba, Semler, Oliver, Schoenau, Eckhard and Duran, Ibrahim ORCID: 0000-0003-4044-8822 (2022). Diagnostic Evaluation of the Functional Muscle-Bone Unit in Children With Cerebral Palsy With and Without Low Trauma Fractures. J. Clin. Densitom., 25 (3). S. 334 - 343. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1559-0747

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Abstract

Children and adolescents with cerebral palsy (CP) are at increased risk of low trauma fractures (LTF) due to low bone mineral content (BMC). The risk of LTFs might be overestimated by only age -and sex adjusted Z-scores for BMC because Z-score based DXA techniques do not take into account other relevant parameters like height, muscle and fat mass. This study aimed to present an update of the functional muscle-bone unit-algorithm (uFMBU-A) to evaluate bone health in children with CP in order to predict the risk of LTF taking into account the parameters sex, age, height, muscle and fat mass. We performed a monocentric retrospective analysis of 177 DXA-scans of children and adolescents with CP aged 8-19. Six of these 177 patients had sus-tained at least 1 LTF. Age-, sex-and size adjusted Z-scores of total body less head (TBLH)-BMC, lean body mass and fat mass were calculated. The uFMBU-A was applied to the study group and results were compared with established Z-score based DXA-measurements and algorithm based diagnostic techniques concerning the prediction of LTF risk. The uFMBU-A had the greatest diagnostic odds ratio (13.3 [95% CI 2.41; 72.9]) of the evaluated predictors with a sensitivity of 50.0% (95% CI 11.8; 88.2), specifity of 93% (95% CI 88.1; 96.3). The uFMBU-A was the most accurate method of the evaluated parameters to predict LTF in children with CP and is recommended when evaluating bone health.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schafmeyer, Leonie UNSPECIFIED UNSPECIFIED UNSPECIFIED Al-Monajjed, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Linden, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunram, Heidrun Lioba UNSPECIFIED UNSPECIFIED UNSPECIFIED Semler, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenau, Eckhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Duran, Ibrahim UNSPECIFIED orcid.org/0000-0003-4044-8822 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-677226
DOI:	10.1016/j.jocd.2022.01.002
Journal or Publication Title:	J. Clin. Densitom.
Volume:	25
Number:	3
Page Range:	S. 334 - 343
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1559-0747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language X-RAY ABSORPTIOMETRY; GROSS MOTOR FUNCTION; BODY-COMPOSITION; MINERAL DENSITY; YOUNG-ADULTS; ADOLESCENTS; MASS; DENSITOMETRY; HEALTH Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67722