Universität zu Köln

Biermann, Lea ORCID: 0000-0001-7834-9366, Wunram, Heidrun Lioba, Pokorny, Lena ORCID: 0000-0001-5638-0813, Breitinger, Eva, Grossheinrich, Nicola ORCID: 0000-0001-6445-3672, Jarczok, Tomasz Antoni and Bender, Stephan ORCID: 0000-0001-8199-3785 (2022). Changes in the TMS-evoked potential N100 in the dorsolateral prefrontal cortex as a function of depression severity in adolescents. J. Neural Transm., 129 (11). S. 1339 - 1353. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Studies using transcranial magnetic stimulation with simultaneous electroencephalography (TMS-EEG) revealed an imbalance between cortical excitation and inhibition (E/I) in the dorsolateral prefrontal cortex (DLPFC) in depression. As adolescence is a developmental period with an increase in depression prevalence and profound neural changes, it is crucial to study the relationship between depression and cortical excitability in adolescence. We aimed to investigate the cortical excitability of the DLPFC in adolescents with depression and a dependency of the TMS-evoked potential N100 on the depression severity. 36 clinical patients (12-18 years of age; 21 females) with a major depressive episode were assessed twice in a longitudinal design: shortly after admission (T0) and after six weeks of intervention (T1). GABA-B-mediated cortical inhibition in the left and right DLPFC, as assessed by the N100, was recorded with EEG. Significantly higher depression scores were reported at T0 compared to T1 (p < 0.001). N100 amplitudes were significantly increased (i.e., more negative) at T0 compared to T1 (p = 0.03). No significant hemispheric difference was found in the N100 component. The correlation between the difference in depression severity and the difference in N100 amplitudes (T0-T1) obtained during stimulation of the left DLPFC did not remain significant after correction for testing in both hemispheres. Higher N100 amplitudes during a state of greater depression severity are suggestive of an E/I imbalance in the DLPFC in adolescents with an acute depressive episode. The N100 reduction potentially reflects a normalization of DLPFC over inhibition in association with decreased depressive symptomatology, indicating severity dependency.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Biermann, Lea UNSPECIFIED orcid.org/0000-0001-7834-9366 UNSPECIFIED Wunram, Heidrun Lioba UNSPECIFIED UNSPECIFIED UNSPECIFIED Pokorny, Lena UNSPECIFIED orcid.org/0000-0001-5638-0813 UNSPECIFIED Breitinger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Grossheinrich, Nicola UNSPECIFIED orcid.org/0000-0001-6445-3672 UNSPECIFIED Jarczok, Tomasz Antoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Bender, Stephan UNSPECIFIED orcid.org/0000-0001-8199-3785 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678321
DOI:	10.1007/s00702-022-02539-9
Journal or Publication Title:	J. Neural Transm.
Volume:	129
Number:	11
Page Range:	S. 1339 - 1353
Date:	2022
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; AMINOBUTYRIC-ACID LEVELS; THETA BURST STIMULATION; LOUDNESS DEPENDENCE; MAJOR DEPRESSION; CHILDRENS DEPRESSION; CORTICAL REACTIVITY; GABA CONCENTRATIONS; BRAIN; EEG Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67832