Universität zu Köln

Khanbabaei, Hashem, Ebrahimi, Saeedeh ORCID: 0000-0003-3117-6669, Garcia-Rodriguez, Juan Luis, Ghasemi, Zahra, Pourghadamyari, Hossein, Mohammadi, Milad ORCID: 0000-0003-1755-108X and Kristensen, Lasse Sommer ORCID: 0000-0002-5980-7939 (2022). Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications. J. Exp. Clin. Cancer Res., 41 (1). LONDON: BMC. ISSN 1756-9966

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Abstract

Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant features to carcinoma cells such as dissemination throughout the organism and resistance to anticancer treatments. During the past decades, an entire class of molecules, called non-coding RNA (ncRNA), has been characterized as a key regulator of almost every cellular process, including EMT. Like protein-coding genes, ncRNAs can be deregulated in cancer, acting as oncogenes or tumor suppressors. The various forms of ncRNAs, including microRNAs, PIWI-interacting RNAs, small nucleolar RNAs, transfer RNA-derived RNA fragments, long non-coding RNAs, and circular RNAs can orchestrate the complex regulatory networks of EMT at multiple levels. Understanding the molecular mechanism underlying ncRNAs in EMT can provide fundamental insights into cancer metastasis and may lead to novel therapeutic approaches. In this review, we describe recent advances in the understanding of ncRNAs in EMT and provide an overview of recent ncRNA applications in the clinic.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Khanbabaei, Hashem UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, Saeedeh UNSPECIFIED orcid.org/0000-0003-3117-6669 UNSPECIFIED Garcia-Rodriguez, Juan Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghasemi, Zahra UNSPECIFIED UNSPECIFIED UNSPECIFIED Pourghadamyari, Hossein UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohammadi, Milad UNSPECIFIED orcid.org/0000-0003-1755-108X UNSPECIFIED Kristensen, Lasse Sommer UNSPECIFIED orcid.org/0000-0002-5980-7939 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679475
DOI:	10.1186/s13046-022-02488-x
Journal or Publication Title:	J. Exp. Clin. Cancer Res.
Volume:	41
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1756-9966
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEGATIVE FEEDBACK LOOP; TGF-BETA; CIRCULAR RNA; E-CADHERIN; TRANSCRIPTION FACTOR; MESSENGER-RNA; MICRORNA THERAPEUTICS; ALTERNATIVE CLEAVAGE; PROMOTES METASTASIS; COLORECTAL-CANCER Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67947