Universität zu Köln

Baneckova, Martina, Michal, Michael ORCID: 0000-0003-4403-7027, Hajkova, Veronika, Haller, Florian, Mosaieby, Elaheh, Salajka, Pavel, Arolt, Christoph, Nachtsheim, Lisa, Michal, Michal, Agaimy, Abbas and Skalova, Alena (2022). Misleading Morphologic and Phenotypic Features (Transdifferentiation) in Solitary Fibrous Tumor of the Head and Neck Report of 3 Cases and Review of the Literature. Am. J. Surg. Pathol., 46 (8). S. 1084 - 1095. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1532-0979

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Abstract

Solitary fibrous tumor (SFT) is a rare fibroblastic neoplasm with potentially malignant behavior that may develop in any anatomic site and may involve the head and neck (H&N) region as well. Although typical SFT has a relatively characteristic morphology, its morphologic spectrum is extraordinarily broad and also includes rare cases with dedifferentiation or transdifferentiation which result in aberrant morphologic and/or immunohistochemical features. However, since virtually all cases are molecularly characterized by NAB2::STAT6 gene fusions, molecular genetic methods or STAT6 immunohistochemistry can be effectively used in confirming the diagnosis. Herein, we report 3 diagnostically challenging H&N SFT cases with an unusual morphology and/or phenotypes closely mimicking other well-known H&N entities. The tumors originated in the oral minor salivary glands, the base of the tongue, and sinonasal tract and closely resembled hyalinizing clear cell carcinoma of the salivary gland, adenocarcinoma not otherwise specified and biphenotypic sinonasal sarcoma, respectively. All cases were positive for cytokeratins, variably expressed S100 protein, showed diffuse nuclear STAT6 positivity, and harbored NAB2::STAT6 gene fusions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baneckova, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Michal, Michael UNSPECIFIED orcid.org/0000-0003-4403-7027 UNSPECIFIED Hajkova, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Haller, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Mosaieby, Elaheh UNSPECIFIED UNSPECIFIED UNSPECIFIED Salajka, Pavel UNSPECIFIED UNSPECIFIED UNSPECIFIED Arolt, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Nachtsheim, Lisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Michal, Michal UNSPECIFIED UNSPECIFIED UNSPECIFIED Agaimy, Abbas UNSPECIFIED UNSPECIFIED UNSPECIFIED Skalova, Alena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680479
DOI:	10.1097/PAS.0000000000001875
Journal or Publication Title:	Am. J. Surg. Pathol.
Volume:	46
Number:	8
Page Range:	S. 1084 - 1095
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1532-0979
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NAB2-STAT6 GENE FUSION; RISK-ASSESSMENT; VARIANTS; DEDIFFERENTIATION; TUMOR/HEMANGIOPERICYTOMA; PROGRESSION; EMPHASIS Multiple languages Pathology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68047