Universität zu Köln

Jonas, Jost B., Zhang, Qi, Xu, Liang, Wei, Wen Bin, Jonas, Rahul A. and Wang, Ya Xing (2023). Parapapillary gamma zone enlargement in a 10-year follow-up: the Beijing Eye Study 2001-2011. Eye, 37 (3). S. 524 - 531. LONDON: SPRINGERNATURE. ISSN 1476-5454

Full text not available from this repository.

Abstract

Purpose To assess prevalence and associated factors of parapapillary gamma zone enlargement (GZE). Methods Using fundus photographs and optical coherence tomographic images of participants of the population-based Beijing Eye Study, we examined gamma zone changes in a 10-year follow-up. Results The study included 89 highly myopic eyes (61 participants; age: 65.0 +/- 9.8 years) and 86 randomly selected non-highly myopic eyes. GZE prevalence was significantly higher in highly myopic eyes than non-highly myopic eyes (75/89; 84%; 95% CI: 77, 92 versus 18/86; 21%; 95% CI:12, 30; p < 0.001). None of the eyes showed a reduction in gamma zone size. Higher prevalence of segmental GZE without enlargement of Bruch's membrane opening (BMO) (mean: 26/175; 14.9%; 95% CI: 9.5, 20.2) was associated with optic disc size reduction (OR: 43.3; 95% CI: 10.9, 172; p < 0.001), disc-fovea distance elongation (OR: 15.4; 95% CI: 3.12, 76.4; p = 0.001) and lower prevalence of high axial myopia (OR: 0.08; 95% CI: 0.01, 0.44; p = 0.001). Higher prevalence of circular GZE (mean: 38/175; 21.7%; 95% CI: 16, 28) was correlated with optic disc enlargement (OR: 4.30; 95% CI: 1.58, 11.7; p = 0.004), and higher prevalence of myopic maculopathy progression (OR: 4.04; 95% CI: 1.60, 10.2; p = 0.003), or alternatively, higher prevalence of high myopia (OR: 4.44; 95% CI: 1.76, 11.2; p = 0.002). Circular GZE or BMO enlargement was associated with lower prevalence of macular BM defect enlargement (p = 0.035). GZE occurred perpendicular to the orientation of myopic lacquer cracks in 12 out of 17 (71%; 95% CI: 46, 95) eyes with lacquer cracks. Segmental GZE occurred in 49 (89%) out of 55 eyes in the same direction as shortening of the disc diameter developed. Conclusions The observations support the possibility of a posterior myopic axial elongation-associated BMO shift, leading to a segmental GZE in non-highly myopic eyes, followed by a circular GZE in highly myopic eyes. Large gamma zone might be protective against macular Bruch's membrane defects.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jonas, Jost B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Qi UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wei, Wen Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Rahul A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Ya Xing UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680600
DOI:	10.1038/s41433-022-01978-8
Journal or Publication Title:	Eye
Volume:	37
Number:	3
Page Range:	S. 524 - 531
Date:	2023
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BETA-ZONE; AXIAL LENGTH; ATROPHY; MYOPIA; ASSOCIATION; GLOBE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68060