Universität zu Köln

Haertel, Julian Alexander, Mueller, Nicole ORCID: 0000-0001-9211-9209, Breuer, Johannes, Jordan, Jens ORCID: 0000-0003-4518-0706, Tank, Jens, Bros, Janina, Seeger, Benedikt, Zollmann, Emily, Bloch, Wilhelm and Grau, Marijke (2022). Influence of 24 h Simulated Altitude on Red Blood Cell Deformability and Hematological Parameters in Patients with Fontan Circulation. Metabolites, 12 (11). BASEL: MDPI. ISSN 2218-1989

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Abstract

Patients with Fontan circulation are particularly dependent on low pulmonary vascular resistance because their lungs are passively perfused. Hypoxia drives pulmonary vasoconstriction; thus, red blood cell (RBC) deformability and stability of hematological parameters might be of particular importance, because alterations during hypoxia might further influence circulation. This study aimed to measure respective parameters in patients with Fontan circulation exposed to normobaric hypoxia. A total of 18 patients with Fontan circulation (16 to 38 years) were exposed to normobaric hypoxia (15.2% ambient oxygen). Blood samples were taken in normoxia, after 24 h in hypoxia, and 60 min after return to normoxia. Blood count, RBC age distribution, EPO, RBC deformability, marker of RBC nitric oxide, oxidative state, and RBC ATP were measured. Hypoxia increased oxidative stress in RBC, but without affecting RBC deformability. RBC age distribution remained unaffected, although EPO concentrations increased, followed by a rise in reticulocyte count at an already high hematocrit. NO metabolism was not affected by hypoxia. Modest normobaric hypoxia for 24 h did not impair RBC deformability in patients with Fontan circulation; however, the oxidative system seemed to be stressed. Given the high baseline Hct in these patients, hypoxia-induced erythropoiesis could adversely affect rheology with more prolonged hypoxia exposure.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haertel, Julian Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Nicole UNSPECIFIED orcid.org/0000-0001-9211-9209 UNSPECIFIED Breuer, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Bros, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Seeger, Benedikt UNSPECIFIED UNSPECIFIED UNSPECIFIED Zollmann, Emily UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Grau, Marijke UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681311
DOI:	10.3390/metabo12111025
Journal or Publication Title:	Metabolites
Volume:	12
Number:	11
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2218-1989
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; ERYTHROCYTE DEFORMABILITY; HYPOBARIC HYPOXIA; ADULT PATIENTS; TRAINING LOW; EXERCISE; PERFORMANCE; CHEMILUMINESCENCE; ERYTHROPOIESIS Multiple languages Biochemistry & Molecular Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68131