Universität zu Köln

Fueessl, Louise, Lau, Tobias, Lean, Isaac, Hasmann, Sandra, Riedl, Bernhard, Arend, Florian M., Sorodoc-Otto, Johanna, Soreth-Rieke, Daniela, Toepfer, Marcell, Rau, Simon, Salihi-Halimi, Haxhrije, Paal, Michael ORCID: 0000-0001-8831-0238, Beuthien, Wilke, Thaller, Norbert, Suttmann, Yana, von Gersdorff, Gero, Regenauer, Ron, Von Bergwelt-Baildon, Anke, Teupser, Daniel, Bruegel, Mathias, Fischereder, Michael and Schoenermarck, Ulf (2022). Diminished Short- and Long-Term Antibody Response after SARS-CoV-2 Vaccination in Hemodialysis Patients. Vaccines, 10 (4). BASEL: MDPI. ISSN 2076-393X

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Abstract

Short-term studies have shown an attenuated immune response in hemodialysis patients after COVID-19-vaccination. The present study examines how antibody response is maintained after vaccination against SARS-CoV-2 in a large population of hemodialysis patients from six outpatient dialysis centers. We retrospectively assessed serum antibody levels against SARS-CoV-2 spike protein and nucleocapsid protein (electrochemiluminescence immunoassays, Roche Diagnostics) after COVID-19-vaccination in 298 hemodialysis and 103 non-dialysis patients (controls), comparing early and late antibody response. Compared to a non-dialysis cohort hemodialysis patients showed a favorable but profoundly lower early antibody response, which decreased substantially during follow-up measurement (median 6 months after vaccination). Significantly more hemodialysis patients had anti-SARS-CoV-2-S antibody titers below 100 U/mL (p < 0.001), which increased during follow-up from 23% to 45% but remained low in the control group (3% vs. 7%). In multivariate analysis, previous COVID-19 infections (p < 0.001) and female gender (p < 0.05) were significantly associated with higher early as well as late antibody vaccine response in hemodialysis patients, while there was a significant inverse correlation between patient age and systemic immunosuppression (p < 0.001). The early and late antibody responses were significantly higher in patients receiving vaccination after a SARS-CoV-2 infection compared to uninfected patients in both groups (p < 0.05). We also note that a higher titer after complete immunization positively affected late antibody response. The observation, that hemodialysis patients showed a significantly stronger decline of SARS-CoV-2 vaccination antibody titers within 6 months, compared to controls, supports the need for booster vaccinations to foster a stronger and more persistent antibody response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fueessl, Louise UNSPECIFIED UNSPECIFIED UNSPECIFIED Lau, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Lean, Isaac UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasmann, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Arend, Florian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorodoc-Otto, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Soreth-Rieke, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Toepfer, Marcell UNSPECIFIED UNSPECIFIED UNSPECIFIED Rau, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Salihi-Halimi, Haxhrije UNSPECIFIED UNSPECIFIED UNSPECIFIED Paal, Michael UNSPECIFIED orcid.org/0000-0001-8831-0238 UNSPECIFIED Beuthien, Wilke UNSPECIFIED UNSPECIFIED UNSPECIFIED Thaller, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Suttmann, Yana UNSPECIFIED UNSPECIFIED UNSPECIFIED von Gersdorff, Gero UNSPECIFIED UNSPECIFIED UNSPECIFIED Regenauer, Ron UNSPECIFIED UNSPECIFIED UNSPECIFIED Von Bergwelt-Baildon, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Teupser, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruegel, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischereder, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenermarck, Ulf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681583
DOI:	10.3390/vaccines10040605
Journal or Publication Title:	Vaccines
Volume:	10
Number:	4
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-393X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAINTENANCE HEMODIALYSIS; BNT162B2 VACCINE Multiple languages Immunology; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68158