Universität zu Köln

Dick, Julia, Tuechler, Anja, Bredart, Anne, Vitinius, Frank, Wassermann, Kirsten, Rhiem, Kerstin and Schmutzler, Rita K. (2022). Psychological factors and the uptake of preventative measures in BRCA1/2 pathogenic variant carriers: results of a prospective cohort study. Hered. Cancer Clin. Pract., 20 (1). LONDON: BMC. ISSN 1897-4287

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Abstract

Background: Women carrying BRCA1/2 pathogenic variants are exposed to elevated risks of developing breast cancer (BC) and are faced by a complex decision-making process on preventative measures, i.e., risk-reducing mastectomy (RRM), and intensified breast surveillance (IBS). In this prospective cohort study we investigated the effect of anxiety, personality factors and coping styles on the decision-making process on risk management options in women with pathogenic variants in BRCA1/2.Methods: Breast cancer unaffected and affected women with a pathogenic variant in the BRCA1 or BRCA2 gene were psychologically evaluated immediately before (T0), 6 to 8 weeks (T1) and 6 to 8 months (T2) after the disclosure of their genetic test results. Uptake of RRM and IBS was assessed at T2. Psychological data were gathered using questionnaires on risk perception, personality factors, coping styles, decisional conflict, depression and anxiety, including the Hospital Anxiety and Depression Scale (HADS). We performed tests on statistical significance and fitted a logistic regression based on significance level.Results: A total of 98 women were included in the analysis. Baseline anxiety levels in women opting for RRM were high but decreased over time, while they increased in women opting for intensified breast surveillance (IBS). Elevated levels of anxiety after genetic test result disclosure (T1) were associated with the decision to undergo RRM (p < 0.01; OR = 1.2, 95% CI = 1.05-1.42), while personal BC history and personality factors seemed to be less relevant.Conclusions: Considering psychosocial factors influencing the decision-making process of women with pathogenic variants in BRCA1/2 may help improving their genetic and psychological counselling. When opting for IBS they may profit from additional medical and psychological counselling.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dick, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Tuechler, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Bredart, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Vitinius, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Wassermann, Kirsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681911
DOI:	10.1186/s13053-022-00244-y
Journal or Publication Title:	Hered. Cancer Clin. Pract.
Volume:	20
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1897-4287
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BILATERAL PROPHYLACTIC MASTECTOMY; QUALITY-OF-LIFE; RISK-REDUCING MASTECTOMY; CONTRALATERAL BREAST-CANCER; LONG-TERM SATISFACTION; HEREDITARY BREAST; MUTATION CARRIERS; DECISION-MAKING; OVARIAN-CANCER; HOSPITAL ANXIETY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68191