Universität zu Köln

Djordjevic, Ilija ORCID: 0000-0002-5810-8626, Liakopoulos, Oliver, Elskamp, Mara, Maier-Trauth, Johanna, Gerfer, Stephen, Muehlbauer, Thomas, Slottosch, Ingo, Kuhn, Elmar, Sabashnikov, Anton, Rademann, Pia, Maul, Alexandra, Paunel-Goerguelue, Adnana, Wahlers, Thorsten and Deppe, Antje Christin (2022). Concomitant Intra-Aortic Balloon Pumping Significantly Reduces Left Ventricular Pressure during Central Veno-Arterial Extracorporeal Membrane Oxygenation-Results from a Large Animal Model. Life-Basel, 12 (11). BASEL: MDPI. ISSN 2075-1729

Full text not available from this repository.

Abstract

(1) Introduction: Simultaneous ECMO and IABP therapy is frequently used. Haemodynamic changes responsible for the success of the concomitant mechanical circulatory support system approach are rarely investigated. In a large-animal model, we analysed haemodynamic parameters before and during ECMO therapy, comparing central and peripheral ECMO circulation with and without simultaneous IABP support. (2) Methods: Thirty-three female pigs were divided into five groups: (1) SHAM, (2) (peripheral)ECMO(-)IABP, (3) (p)ECMO(+)IABP, (4) (central)ECMO(-)IABP, and (5) (c)ECMO(+)IABP. Pigs were cannulated in accordance with the group and supported with ECMO (+/- IABP) for 10 h. Systemic haemodynamics, cardiac index (CI), and coronary and carotid artery blood flow were determined before, directly after, and at five and ten hours on extracorporeal support. Systemic inflammation (IL-6; IL-10; TNF alpha; IFN gamma), immune response (NETs; cf-DNA), and endothelial injury (ET-1) were also measured. (3) Results: IABP support during antegrade ECMO circulation led to a significant reduction of left ventricular pressure in comparison to retrograde flow in (p)ECMO(-)IABP and (p)ECMO(+)IABP. Blood flow in the left anterior coronary and carotid artery was not affected by extracorporeal circulation. (4) Conclusions: Concomitant central ECMO and IABP therapy leads to significant reduction of intracavitary cardiac pressure, reduces cardiac work, and might therefore contribute to improved recovery in ECMO patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Djordjevic, Ilija UNSPECIFIED orcid.org/0000-0002-5810-8626 UNSPECIFIED Liakopoulos, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Elskamp, Mara UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier-Trauth, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerfer, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED Muehlbauer, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Slottosch, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED Rademann, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Maul, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Paunel-Goerguelue, Adnana UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Deppe, Antje Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-681994
DOI:	10.3390/life12111859
Journal or Publication Title:	Life-Basel
Volume:	12
Number:	11
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-1729
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LIFE-SUPPORT; CARDIOGENIC-SHOCK; GRAFT FLOW; ECMO; IABP; COUNTERPULSATION Multiple languages Biology; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68199