Universität zu Köln

Snelders, Nick C. C., Boshoven, Jordi C. C., Song, Yin, Schmitz, Natalie, Fiorin, Gabriel L. L., Rovenich, Hanna ORCID: 0000-0001-6138-4480, van den Berg, Grardy C. M., Torres, David E. E., Petti, Gabriella C. C., Prockl, Zoe ORCID: 0000-0001-6802-5800, Faino, Luigi, Seidl, Michael F. F. and Thomma, Bart P. H. J. (2023). A highly polymorphic effector protein promotes fungal virulence through suppression of plant-associated Actinobacteria. New Phytol., 237 (3). S. 944 - 959. HOBOKEN: WILEY. ISSN 1469-8137

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Abstract

Plant pathogens secrete effector proteins to support host colonization through a wide range of molecular mechanisms, while plant immune systems evolved receptors to recognize effectors or their activities to mount immune responses to halt pathogens. Importantly, plants do not act as single organisms, but rather as holobionts that actively shape their microbiota as a determinant of health. The soil-borne fungal pathogen Verticillium dahliae was recently demonstrated to exploit the VdAve1 effector to manipulate the host microbiota to promote vascular wilt disease in the absence of the corresponding immune receptor Ve1. We identify a multiallelic V. dahliae gene displaying c. 65% sequence similarity to VdAve1, named VdAve1-like (VdAve1L), which shows extreme sequence variation, including alleles that encode dysfunctional proteins, indicative of selection pressure to overcome host recognition. We show that the orphan cell surface receptor Ve2, encoded at the Ve locus, does not recognize VdAve1L. Additionally, we demonstrate that the full-length variant VdAve1L2 possesses antimicrobial activity, like VdAve1, yet with a divergent activity spectrum, that is exploited by V. dahliae to mediate tomato colonization through the direct suppression of antagonistic Actinobacteria in the host microbiota. Our findings open up strategies for more targeted biocontrol against microbial plant pathogens.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Snelders, Nick C. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boshoven, Jordi C. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Yin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Natalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Fiorin, Gabriel L. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rovenich, Hanna UNSPECIFIED orcid.org/0000-0001-6138-4480 UNSPECIFIED van den Berg, Grardy C. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Torres, David E. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petti, Gabriella C. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prockl, Zoe UNSPECIFIED orcid.org/0000-0001-6802-5800 UNSPECIFIED Faino, Luigi UNSPECIFIED UNSPECIFIED UNSPECIFIED Seidl, Michael F. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomma, Bart P. H. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-682130
DOI:	10.1111/nph.18576
Journal or Publication Title:	New Phytol.
Volume:	237
Number:	3
Page Range:	S. 944 - 959
Date:	2023
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-8137
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATHOGEN CLADOSPORIUM-FULVUM; GENOME EVOLUTION; READ ALIGNMENT; 2-SPEED GENOME; VERTICILLIUM; TOMATO; RESISTANCE; DAHLIAE; GENES; RACE Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68213