Universität zu Köln

Pasha, Raabya, Azmi, Shazli, Ferdousi, Maryam, Kalteniece, Alise, Bashir, Bilal ORCID: 0000-0003-3733-8331, Gouni-Berthold, Ioanna, Malik, Rayaz A. and Soran, Handrean (2022). Lipids, Lipid-Lowering Therapy, and Neuropathy: A Narrative Review. Clin. Ther., 44 (7). S. 1012 - 1026. BRIDGEWATER: ELSEVIER. ISSN 1879-114X

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Abstract

Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the mainstay of treatment for hypercholesterolemia as they effectively reduce LDL-C levels and risk of atherosclerotic cardiovascular disease. Apart from hyperglycemia, dyslipidemia and HDL dysfunction are known risk factors for neuropa-thy in people with obesity and diabetes. Although there are case reports of statin-induced neuropathy, ad hoc analyses of clinical trials and observational studies have shown that statins may improve peripheral neuropathy. However, large randomized controlled trials and meta -analyses of cardiovascular outcome trials with statins and other lipid-lowering drugs have not reported on neuropathy outcomes. Because neuropathy was not a prespecified outcome in major cardiovascular trials, one cannot conclude whether statins or other lipid -lowering therapies increase or decrease the risk of neuropathy. The aim of this review was to assess if statins have beneficial or detrimental effects on neuropathy and whether there is a need for large well-powered interventional studies using objective neuropathy end points. (Clin Ther. 2022;44:1012- (c) 2022 Published Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pasha, Raabya UNSPECIFIED UNSPECIFIED UNSPECIFIED Azmi, Shazli UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferdousi, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalteniece, Alise UNSPECIFIED UNSPECIFIED UNSPECIFIED Bashir, Bilal UNSPECIFIED orcid.org/0000-0003-3733-8331 UNSPECIFIED Gouni-Berthold, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Malik, Rayaz A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Soran, Handrean UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683080
DOI:	10.1016/j.clinthera.2022.03.013
Journal or Publication Title:	Clin. Ther.
Volume:	44
Number:	7
Page Range:	S. 1012 - 1026
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	BRIDGEWATER
ISSN:	1879-114X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HMG-COA REDUCTASE; LOW-DENSITY-LIPOPROTEIN; PERIPHERAL NEUROPATHY; CARDIOVASCULAR-DISEASE; DIABETIC-NEUROPATHY; STATIN THERAPY; LDL CHOLESTEROL; DOUBLE-BLIND; QUANTITATIVE-EVALUATION; RISK-FACTORS Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68308